PXD008998

PXD008998 is an original dataset announced via ProteomeXchange.

Title	Mitochondria enriched proteome from heart of heart Sod2 knockout mice LC MS/MS
Description	Superoxide dismutases (SOD) convert superoxide to hydrogen peroxide and therefore provide an important ROS defence mechanism. SOD2 is the sole superoxide dismutase in mitochondrial matrix and thus SOD2 knockout mice can be utilized to analyse what effects increased oxidative stress has on mitochondrial proteome. To this end, we purified heart mitochondria from heart Sod2 knockout mice (Sod2 Ckmm cre) and controls and analysed their proteome with label free LS MS/MS.
HostingRepository	PRIDE
AnnounceDate	2018-06-06
AnnouncementXML	Submission_2018-06-06_02:47:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinping Li
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-20 08:31:46	ID requested
⏵ 1	2018-06-06 02:47:50	announced

Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG, Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res, 46(13):6642-6669(2018) [pubmed]

curator keyword: Biological

submitter keyword: C57BL/6N, mouse, superoxide dismutase 2, SOD2, MnSOD2, mitochondria, heart

Xinping Li
contact affiliation	Max Planck Institute for Biology of Ageing, Germany
contact email	xli@age.mpg.de
lab head
Xinping Li
contact affiliation	Max Planck Institute for Biology of Ageing
contact email	xli@age.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD008998

PRIDE project URI

• PRIDE
  1. PXD008998
     1. Label: PRIDE project
     2. Name: Mitochondria enriched proteome from heart of heart Sod2 knockout mice LC MS/MS