PXD008995

PXD008995 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold
Description	Wild-type or TRAF2 mutated melanoma cells were treated with TNFalpha or co-cultured with activated T-cells for various short incubations (5min to 6 hours). Cells were harvested and analyzed using mass spectrometry for treatment induced changes at the proteome and phosphoproteome level.
HostingRepository	PRIDE
AnnounceDate	2025-02-14
AnnouncementXML	Submission_2025-02-14_07:29:39.058.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kelly Stecker
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-20 05:17:35	ID requested
⏵ 1	2025-02-14 07:29:39	announced

Publication List

Vredevoogd DW, Kuilman T, Ligtenberg MA, Boshuizen J, Stecker KE, de Bruijn B, Krijgsman O, Huang X, Kenski JCN, Lacroix R, Mezzadra R, Gomez-Eerland R, Yildiz M, Dagidir I, Apriamashvili G, Zandhuis N, van der Noort V, Visser NL, Blank CU, Altelaar M, Schumacher TN, Peeper DS, Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell, 178(3):585-599.e15(2019) [pubmed]
10.1016/j.cell.2019.06.014;

Vredevoogd DW, Kuilman T, Ligtenberg MA, Boshuizen J, Stecker KE, de Bruijn B, Krijgsman O, Huang X, Kenski JCN, Lacroix R, Mezzadra R, Gomez-Eerland R, Yildiz M, Dagidir I, Apriamashvili G, Zandhuis N, van der Noort V, Visser NL, Blank CU, Altelaar M, Schumacher TN, Peeper DS, Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell, 178(3):585-599.e15(2019) [pubmed]

10.1016/j.cell.2019.06.014;

Keyword List

curator keyword: Biomedical
submitter keyword: T cell,Melanoma, phosphorylation, TRAF2

curator keyword: Biomedical

submitter keyword: T cell,Melanoma, phosphorylation, TRAF2

Contact List

Kelly Stecker
contact affiliation	Assistant Professor at Biomolecular Mass Spectrometry and Proteomics, Utrecht University Proteomics facility anager at Netherlands Cancer Institute
contact email	k.e.stecker@uu.nl
lab head
Kelly Stecker
contact affiliation	Utrecht University
contact email	k.e.stecker@uu.nl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD008995
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD008995

PRIDE project URI

Repository Record List

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