PXD008990

PXD008990 is an original dataset announced via ProteomeXchange.

Title	Glycomic and Proteomic changes in aging brain nigrostriatal pathway
Description	This study identifies the age related changes in glycan receptors of heparan sulfate (HS) proteoglycan (receptor for rAAV2), and/or N-glycans with terminal galactose (receptor for rAAV9) and proteomics for receptors and co-receptors of adeno-associated virus in the nigro-striatal region of the brain. We analyzed the striatum and substantia nigra for changes in HS, N-glycans and proteomic signatures in young versus aged rat brain nigro-striatum from histological sections. These studies provide insight into age- and brain region-specific changes in glycan receptors and proteomics that will inform design of improved viral vectors for Parkinson’s disease gene therapy.
HostingRepository	PRIDE
AnnounceDate	2018-06-27
AnnouncementXML	Submission_2019-02-15_09:05:07.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rekha Raghunathan
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-20 01:32:31	ID requested
1	2018-06-27 05:37:04	announced
⏵ 2	2019-02-15 09:05:08	announced	Updated publication reference for PubMed record(s): 29915149.

Raghunathan R, Polinski NK, Klein JA, Hogan JD, Shao C, Khatri K, Leon D, McComb ME, Manfredsson FP, Sortwell CE, Zaia J, Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway. Mol Cell Proteomics, 17(9):1778-1787(2018) [pubmed]

curator keyword: Biological

submitter keyword: glycomic, proteomic, label-free proteomics, N-glycans, heparan sulfate, adeno-associated virus, aging nigro-striatal pathway, mass spectrometry, hilic, hilic-wax, reverse phase, LC-MSMS, Parkinson’s disease, gene therapy

Joseph Zaia
contact affiliation	Biochemistry, Boston University
contact email	jzaia@bu.edu
lab head
Rekha Raghunathan
contact affiliation	Boston University
contact email	rrekha@bu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD008990

PRIDE project URI

• PRIDE
  1. PXD008990
     1. Label: PRIDE project
     2. Name: Glycomic and Proteomic changes in aging brain nigrostriatal pathway