PXD008984

PXD008984 is an original dataset announced via ProteomeXchange.

Title	Identification of changes in the LNZ308 HLA immunopeptidome after virotherapy, irradiation and chemotherapy
Description	Glioblastoma is an aggressive incurable primary malignant brain tumor. Measles virus (MeV) therapy is a promising upcoming treatment strategy with proven preclinical efficacy and clinical safety. Using RNA Sequencing and immunopeptidome analyses, we aimed at identifying a synergistic combination regimen of MeV with conventional therapeutic strategies for glioblastoma patients, i.e. radiotherapy and temozolomide or lomustine, and to understand the underlying molecular mechanism.
HostingRepository	PRIDE
AnnounceDate	2019-02-19
AnnouncementXML	Submission_2019-02-19_08:50:07.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Ghosh
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-19 07:56:39	ID requested
⏵ 1	2019-02-19 08:50:09	announced

Rajaraman S, Canjuga D, Ghosh M, Codrea MC, Sieger R, Wedekink F, Tatagiba M, Koch M, Lauer UM, Nahnsen S, Rammensee HG, M, ü, hlebach MD, Stevanovic S, Tabatabai G, Measles Virus-Based Treatments Trigger a Pro-inflammatory Cascade and a Distinctive Immunopeptidome in Glioblastoma. Mol Ther Oncolytics, 12():147-161(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Human, LCMS, Glioblastoma, oncolytic virotherapy, immunopeptidome, personalized immunotherapy

Prof. Dr. Stefan Stevanović
contact affiliation	Department of Immunology, Interfaculty Institute for Cell Biology, Tübingen, Germany
contact email	stefan.stevanovic@uni-tuebingen.de
lab head
Michael Ghosh
contact affiliation	Department of Immunology, Tübingen
contact email	Michaelghosh@gmx.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD008984

PRIDE project URI

• PRIDE
  1. PXD008984
     1. Label: PRIDE project
     2. Name: Identification of changes in the LNZ308 HLA immunopeptidome after virotherapy, irradiation and chemotherapy