PXD008963

PXD008963 is an original dataset announced via ProteomeXchange.

Title	MudPIT analyses of the proteins associated with Kelch-like protein 6 (KLHL6) in a human multiple myeloma cell line, ARP-1, and in HEK293T cells
Description	Kelch-like protein 6 (KLHL6) is a highly conserved and uncharacterized BTB-Kelch protein with a lymphoid tissue-restricted expression pattern. To gain insight into the molecular function of KLHL6 and to understand the impact of the cancer-associated mutations, we compared the protein interactome of KLHL6(WT) to that of the cancer mutant KLHL6(L65P), a BTB-domain mutant frequently mutated in B-cell cancers. FLAG-KLHL6(WT) or FLAG-KLHL6(L65P) complexes were biochemically immunopurified from two different cell lines (HEK293T and ARP-1).
HostingRepository	PRIDE
AnnounceDate	2018-03-27
AnnouncementXML	Submission_2018-03-27_06:59:07.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD008963
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Laurence Florens
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-15 02:43:35	ID requested
1	2018-03-27 06:48:43	announced
⏵ 2	2018-03-27 06:59:08	announced	Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Kelch-like protein 6 (KLHL6), diffuse large B-cell lymphoma (DLBCL), Cullin-Ring ubiquitin ligase (CRL),

Laurence Florens
contact affiliation	The Stowers Institute for Medical Research
contact email	laf@stowers.org
lab head
Laurence Florens
contact affiliation	Proteomics
contact email	laf@stowers.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/03/PXD008963

PRIDE project URI

• PRIDE
  1. PXD008963
     1. Label: PRIDE project
     2. Name: MudPIT analyses of the proteins associated with Kelch-like protein 6 (KLHL6) in a human multiple myeloma cell line, ARP-1, and in HEK293T cells