PXD008955

PXD008955 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Protein quality control by MARCH6/TRC8
Description	Forward genetic screens in human cells we find that the proteasome-mediated degradation of the soluble misfolded reporter, mCherry-CL1, involves two ER-resident E3 ligases, MARCH6 and TRC8. To identify a more physiological correlate we used quantitative mass spectrometry and found that TRC8 and MARCH6 depletion altered the turnover of the tail-anchored protein Heme-Oxygenase-1 (HO-1).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:43:01.622.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	James Williamson
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-14 01:53:52	ID requested
1	2018-04-18 08:06:03	announced
⏵ 2	2024-10-22 04:43:09	announced	2024-10-22: Updated project metadata.

Publication List

Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA, MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins. EMBO Rep, 19(5):(2018) [pubmed]
10.15252/embr.201745603;

Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA, MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins. EMBO Rep, 19(5):(2018) [pubmed]

10.15252/embr.201745603;

Keyword List

curator keyword: Biological
submitter keyword: ERAD, MARCH6, Intramembrane proteolysis, TRC8,Protein quality control

curator keyword: Biological

submitter keyword: ERAD, MARCH6, Intramembrane proteolysis, TRC8,Protein quality control

Contact List

James Nathan
contact affiliation	Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, CB2 0XY, UK
contact email	jan33@cam.ac.uk
lab head
James Williamson
contact affiliation	University of Cambridge
contact email	jcw76@cam.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/04/PXD008955
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/04/PXD008955

PRIDE project URI

Repository Record List

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