PXD008945

PXD008945 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterization of plasma-derived exosomes from P. vivax infected FRG huHep mice
Description	This project focused in the proteomic characterization of plasma-derived exosomes from Plasmodium vivax infected FRG huHep mice, a suitable in vivo model for the development of pre-erythrocytic stages of this parasite. P. vivax is responsible for the vast majority of Malaria cases outside Africa. This parasite evolved a latent liver stage form called hypnozoite that cannot be detected using the current diagnostic methods. This represent a major limitation to the Malaria elimination goal. Exosomes are extracellular vesicles involved in intercellular communication and in a large variety of physiological functions. Recently, this vesicles have been recognized for the immense potential to be used as biomarkers in the context of non-invasive diagnostic approaches from liquid biopsies. The exploration of the protein content of exosomes secreted into the bloodstream of P. vivax infected FRG huHep mice represents an interesting approach to tackle the big challenge of identifying a hypnozoite biomarker which in the future could help to identify hypnozoites carriers in Malaria vivax relapsing patients.
HostingRepository	PRIDE
AnnounceDate	2018-07-16
AnnouncementXML	Submission_2018-07-16_05:36:28.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hernando A del Portillo
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Plasmodium vivax; NCBI TaxID: 5855; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-13 05:46:49	ID requested
⏵ 1	2018-07-16 05:36:29	announced

Gualdr, ó, n-L, ó, pez M, Flannery EL, Kangwanrangsan N, Chuenchob V, Fernandez-Orth D, Segui-Barber J, Royo F, Falc, ó, n-P, é, rez JM, Fernandez-Becerra C, Lacerda MVG, Kappe SHI, Sattabongkot J, Gonzalez JR, Mikolajczak SA, Del Portillo HA, Proteins in Plasma-Derived Exosomes From Malaria-Infected Liver-Chimeric Humanized Mice. Front Microbiol, 9():1271(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: humanized liver chimeric mouse, exosomes, plasmodium vivax

Hernando A del Portillo
contact affiliation	- Institute for Global Health, Hospital Clinic, Universitat de Barcelona. Barcelona. Spain. - Catalan Institution for Research and Advanced Studies, Barcelona, Spain. - Institute for Health Sciences Germans Trias I Pujol. Barcelona, Spain
contact email	hernandoa.delportillo@isglobal.org
lab head
Hernando A del Portillo
contact affiliation	ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain IGTP Institut d’Investigació Germans Trias i Pujol, Badalona, Spain
contact email	hernandoa.delportillo@isglobal.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD008945

PRIDE project URI

• PRIDE
  1. PXD008945
     1. Label: PRIDE project
     2. Name: Proteomic characterization of plasma-derived exosomes from P. vivax infected FRG huHep mice