PXD008934 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Characterization of proteomic changes in human heart failure |
Description | The microtubule (MT) cytoskeleton can provide a mechanical resistance that can impede the motion of contracting cardiomyocytes. Yet a role of the MT network in human heart failure is unexplored. Here we utilize mass spectrometry to characterize changes to the cytoskeleton in human heart failure. Proteomic analysis of left ventricle tissue reveals a consistent upregulation and stabilization of intermediate filaments and MTs in human heart failure. This dataset includes left ventricular (LV) myocardium from 34 human hearts – either non-failing (NF) or failing hearts. NF hearts are subdivided into normal or compensated hypertrophy (cHyp), while failing hearts are subdivided into ischemic cardiomyopathy (ICM), dilated cardiomyopathy (DCM), and hypertrophic cardiomyopathy with preserved or reduced ejection fraction (HCMpEF and HCMrEF, respectively). Further details on patient classification and in vivo parameters on each heart are listed in sample details.txt. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:43:28.662.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Benjamin Prosser |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-02-12 08:38:42 | ID requested | |
1 | 2018-06-06 07:01:02 | announced | |
2 | 2018-06-18 01:03:50 | announced | Updated publication reference for PubMed record(s): 29892068. |
⏵ 3 | 2024-10-22 04:43:36 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/s41591-018-0046-2; |
Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL, Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nat Med, 24(8):1225-1233(2018) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Q-Exactive (Thermo Scientific),Human left ventricular tissue |
Contact List
Benjamin L. Prosser |
contact affiliation | Department of Physiology, Pennsylvania Muscle Institute, Penn Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. |
contact email | bpros@pennmedicine.upenn.edu |
lab head | |
Benjamin Prosser |
contact affiliation | University of Pennsylvania |
contact email | bpros@pennmedicine.upenn.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008934
- Label: PRIDE project
- Name: Characterization of proteomic changes in human heart failure