PXD008934

PXD008934 is an original dataset announced via ProteomeXchange.

Title	Characterization of proteomic changes in human heart failure
Description	The microtubule (MT) cytoskeleton can provide a mechanical resistance that can impede the motion of contracting cardiomyocytes. Yet a role of the MT network in human heart failure is unexplored. Here we utilize mass spectrometry to characterize changes to the cytoskeleton in human heart failure. Proteomic analysis of left ventricle tissue reveals a consistent upregulation and stabilization of intermediate filaments and MTs in human heart failure. This dataset includes left ventricular (LV) myocardium from 34 human hearts – either non-failing (NF) or failing hearts. NF hearts are subdivided into normal or compensated hypertrophy (cHyp), while failing hearts are subdivided into ischemic cardiomyopathy (ICM), dilated cardiomyopathy (DCM), and hypertrophic cardiomyopathy with preserved or reduced ejection fraction (HCMpEF and HCMrEF, respectively). Further details on patient classification and in vivo parameters on each heart are listed in sample details.txt.
HostingRepository	PRIDE
AnnounceDate	2018-06-06
AnnouncementXML	Submission_2018-06-18_01:03:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Benjamin Prosser
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-12 08:38:42	ID requested
1	2018-06-06 07:01:02	announced
⏵ 2	2018-06-18 01:03:50	announced	Updated publication reference for PubMed record(s): 29892068.

Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL, Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nat Med, 24(8):1225-1233(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Human left ventricular tissue, Q-Exactive (Thermo Scientific)

Benjamin L. Prosser
contact affiliation	Department of Physiology, Pennsylvania Muscle Institute, Penn Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
contact email	bpros@pennmedicine.upenn.edu
lab head
Benjamin Prosser
contact affiliation	University of Pennsylvania
contact email	bpros@pennmedicine.upenn.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD008934

PRIDE project URI

• PRIDE
  1. PXD008934
     1. Label: PRIDE project
     2. Name: Characterization of proteomic changes in human heart failure