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PXD008934

PXD008934 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterization of proteomic changes in human heart failure
DescriptionThe microtubule (MT) cytoskeleton can provide a mechanical resistance that can impede the motion of contracting cardiomyocytes. Yet a role of the MT network in human heart failure is unexplored. Here we utilize mass spectrometry to characterize changes to the cytoskeleton in human heart failure. Proteomic analysis of left ventricle tissue reveals a consistent upregulation and stabilization of intermediate filaments and MTs in human heart failure. This dataset includes left ventricular (LV) myocardium from 34 human hearts – either non-failing (NF) or failing hearts. NF hearts are subdivided into normal or compensated hypertrophy (cHyp), while failing hearts are subdivided into ischemic cardiomyopathy (ICM), dilated cardiomyopathy (DCM), and hypertrophic cardiomyopathy with preserved or reduced ejection fraction (HCMpEF and HCMrEF, respectively). Further details on patient classification and in vivo parameters on each heart are listed in sample details.txt.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:43:28.662.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBenjamin Prosser
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-02-12 08:38:42ID requested
12018-06-06 07:01:02announced
22018-06-18 01:03:50announcedUpdated publication reference for PubMed record(s): 29892068.
32024-10-22 04:43:36announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41591-018-0046-2;
Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL, Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nat Med, 24(8):1225-1233(2018) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Q-Exactive (Thermo Scientific),Human left ventricular tissue
Contact List
Benjamin L. Prosser
contact affiliationDepartment of Physiology, Pennsylvania Muscle Institute, Penn Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
contact emailbpros@pennmedicine.upenn.edu
lab head
Benjamin Prosser
contact affiliationUniversity of Pennsylvania
contact emailbpros@pennmedicine.upenn.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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