PXD008894

PXD008894 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterisation of lysosomal and mitochondrial perturbations in human iPSC-derived neurons with PARK2 mutation
Description	Mitochondrial dysfunction plays a major role in the pathogenesis of sporadic Parkinson’s disease (PD) and familial PD caused by mutations in the PARK2 gene. The protein, parkin, is vital for mitochondrial function, but the lack of key PD phenotypes in PARK2 knockout (KO) rodent models has hindered investigations into parkin’s role in PD pathogenesis. Human isogenic induced pluripotent stem cell (iPSC) lines with and without PARK2 KO enable studies of the effect of parkin dysfunction in dopaminergic neuronal cultures.
HostingRepository	PRIDE
AnnounceDate	2019-07-26
AnnouncementXML	Submission_2019-08-02_03:55:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pia Jensen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-08 01:32:57	ID requested
1	2019-07-26 09:17:53	announced
⏵ 2	2019-08-02 03:55:51	announced	Updated publication reference for PubMed record(s): 31333417.

Bogetofte H, Jensen P, Ryding M, Schmidt SI, Okarmus J, Ritter L, Worm CS, Hohnholt MC, Azevedo C, Roybon L, Bak LK, Waagepetersen H, Ryan BJ, Wade-Martins R, Larsen MR, Meyer M, Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons. Front Cell Neurosci, 13():297(2019) [pubmed]

curator keyword: Biological

submitter keyword: Human, iPSC, PARK2, LC-MSMS, TMT, mitochondria

Martin Røssel Larsen
contact affiliation	Department of Biochemistry and Molecular Biology, Protein Research group, University of Southern Denmark, Odense, Denmark
contact email	mrl@bmb.sdu.dk
lab head
Pia Jensen
contact affiliation	University of Southern Denmark
contact email	pjensen@bmb.sdu.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD008894

PRIDE project URI

• PRIDE
  1. PXD008894
     1. Label: PRIDE project
     2. Name: Proteomic characterisation of lysosomal and mitochondrial perturbations in human iPSC-derived neurons with PARK2 mutation