PXD008839

PXD008839 is an original dataset announced via ProteomeXchange.

Title	Interactome of the two T. brucei Poly(A) binding protein paralogs PABP1 and PABP2
Description	Poly(A) binding proteins (PABPs) regulate mRNA fate by controlling mRNA stability and translation through interactions with both the poly(A) tail and eIF4F complex. Here we identified a protein interaction cohort for both T. brucei PABPs by cryo-mill/affinity purification-mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2018-07-16
AnnouncementXML	Submission_2018-07-30_02:27:58.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martin Zoltner
SpeciesList	scientific name: Trypanosoma brucei; NCBI TaxID: 5691;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-01 10:02:18	ID requested
1	2018-07-16 03:42:37	announced
⏵ 2	2018-07-30 02:27:59	announced	Updated publication reference for PubMed record(s): 30040867.

Zoltner M, Krienitz N, Field MC, Kramer S, Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA. PLoS Negl Trop Dis, 12(7):e0006679(2018) [pubmed]

curator keyword: Biological

submitter keyword: Trypanosoma brucei, Poly(A) binding, PABP1, PABP2, mRNA stability, interactome

Mark C. Field
contact affiliation	Wellcome Trust Centre for Anti-Infectives Research School of Life Sciences University of Dundee Dundee DD1 5EH
contact email	mfield@mac.com
lab head
Martin Zoltner
contact affiliation	Division of Biological Chemistry & Drug Discovery School of Life Sciences University of Dundee Dundee DD1 5EH
contact email	m.zoltner@dundee.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD008839

PRIDE project URI

• PRIDE
  1. PXD008839
     1. Label: PRIDE project
     2. Name: Interactome of the two T. brucei Poly(A) binding protein paralogs PABP1 and PABP2