Updated publication reference for PubMed record(s): 30503828. Tobacco mosaic virus (TMV) became one of the model virus for fundamental biological research and understanding of the host-pathogen interaction. It utilizes host machinery smartly to complete the life cycle, though many parts of life cycle remained a mystery, such as host factors involved in virus replication processes. We utilized the 8-Plex iTRAQ study to understand host-pathogen interaction between TMV and host tobacco.