PXD008835 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Data in support of Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with Etomoxir or Interferon-beta |
Description | Multiple Sclerosis is a neurogenerative disease, where inflammation plays an essential role and the loss of tolerance for self produces proteins is a key feature. To investigate the autoimmune response, we use serum from experimental autoimmune encephalomyelitis (EAE) induced rats and investigate autoantibody chance in connection with induced disease and treatment with Etomoxir or Interferon-beta. Several significant differences in suggested antigens were identified comparing healthy, diseased and treated groups, suggesting a role of these antigens in the progression of Multiple Sclerosis. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_03:59:18.787.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Allan Stensballe |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | iodoacetamide derivatized residue; deamidated residue; L-citrulline |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-02-01 09:42:40 | ID requested | |
1 | 2018-05-14 02:32:00 | announced | |
⏵ 2 | 2024-10-22 03:59:26 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/s41598-018-25391-y; |
M, ΓΈ, rkholt AS, Kastaniegaard K, Trabjerg MS, Gopalasingam G, Niganze W, Larsen A, Stensballe A, Nielsen S, Nieland JD, . Sci Rep, 8(1):7092(2018) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Multiple Sclerosis, Autoantibodies, Experimental autoimmune encephalomyelitis, rat model, Inflammation, Autoantigens, Etomoxir |
Contact List
Allan Stensballe |
contact affiliation | Laboratory for Medical Mass Spectrometry Department of Health Science and Technology Aalborg University | Denmark |
contact email | as@hst.aau.dk |
lab head | |
Allan Stensballe |
contact affiliation | Aalborg University |
contact email | as@hst.aau.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD008835 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008835
- Label: PRIDE project
- Name: Data in support of Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with Etomoxir or Interferon-beta