PXD008818

PXD008818 is an original dataset announced via ProteomeXchange.

Title	Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance
Description	Myopia (short-sightedness) affects approximately 1.4 billion people worldwide, many of whom will become blind from secondary ophthalmic conditions. The pathophysiology of myopia has been investigated by rearing young animals with monocular negative lenses or occluders that stimulate excessive ocular growth. Although a wide range of gene and protein expression changes have been identified in these myopia models, how these expression responses vary across different ocular growth conditions (including normal ocular development and hyperopia induced by positive lenses) remains poorly understood. Accordingly, this study has examined the trajectory of protein pathway expression shifts during normal development, and lens-induced myopia and hyperopia, in the widely used chick model.
HostingRepository	PRIDE
AnnounceDate	2018-08-13
AnnouncementXML	Submission_2019-02-26_07:57:36.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD008818
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Pierre Faou
SpeciesList	scientific name: Gallus gallus (Chicken); NCBI TaxID: 9031;
ModificationList	Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-31 03:03:14	ID requested
1	2018-08-13 11:03:55	announced
⏵ 2	2019-02-26 07:57:37	announced	Updated publication reference for PubMed record(s): 30157773.

Riddell N, Faou P, Crewther SG, Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance. BMC Dev Biol, 18(1):18(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Myopia, Chiken, LFQ, Mass spectrometry, proteomics

Pierre Faou
contact affiliation	Department of Biochemistry and Genetics, La Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, VIC, Australia
contact email	p.faou@latrobe.edu.au
lab head
Pierre Faou
contact affiliation	La Trobe University
contact email	P.faou@latrobe.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD008818

PRIDE project URI

• PRIDE
  1. PXD008818
     1. Label: PRIDE project
     2. Name: Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance