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PXD008784

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2018-04-16
  • AnnouncementXML: Submission_2018-04-16_02:10:41.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: MATEUSZ KUDELKO
  • Title: SM/J mice display spontaneous early onset disc degeneration link to ion transport system and matrisome changes
  • Description: To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a good and bad intervertebral disc. Using a quantitative proteomic approach, we compared methodically the differences existing between a mouse model known as good healer LG/J to another mouse model characterize as bad healer SM/J. A total of 5245 proteins were identified. By assessing the overlap of the NP LG/J and SM/J proteomic signature with a list of over 1000 matrisomal proteins generated by Naba and co-workers (33), we provide a first comprehensive comparison of NP IVD matrix composition in a good and bad condition and identify potential changes that are fundamental for maintenance of a healthy disc.
  • SpeciesList: scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
  • ModificationList: iodoacetamide derivatized residue
  • Instrument: Orbitrap Fusion Lumos

Dataset History

VersionDatetimeStatusChangeLog Entry
02018-01-29 03:06:01ID requested
12018-04-16 02:10:42announced

Publication List

  1. Zhang Y, Xiong C, Kudelko M, Li Y, Wang C, Wong YL, Tam V, Rai MF, Cheverud J, Lawson HA, Sandell L, Chan WCW, Cheah KSE, Sham PC, Chan D, Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events. Matrix Biol, ():(2018) [pubmed]

Keyword List

  1. curator keyword: Biomedical
  2. submitter keyword: Mouse intervertebral disc, proteomic, nucleus pulposus, LG/J and SM/J.

Contact List

    Professor Danny Chan
    • contact affiliation: S Y and H Y Cheng Professor in Stem Cell Biology and Regenerative Medicine Assistant Dean (Research postgraduate studies), Faculty of Medicine Professor (School of Biomedical Sciences), Faculty of Medicine Deputy Director (Education and Development of Research Integrity), HKU
    • contact email: chand@hku.hk
    • lab head:
    MATEUSZ KUDELKO
    • contact affiliation: HKU Biochemistry
    • contact email: mkudelko@gmail.com
    • dataset submitter:

Full Dataset Link List

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  2. PRIDE project URI
Repository Record List
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