PXD008784

PXD008784 is an original dataset announced via ProteomeXchange.

Title	SM/J mice display spontaneous early onset disc degeneration link to ion transport system and matrisome changes
Description	To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a good and bad intervertebral disc. Using a quantitative proteomic approach, we compared methodically the differences existing between a mouse model known as good healer LG/J to another mouse model characterize as bad healer SM/J. A total of 5245 proteins were identified. By assessing the overlap of the NP LG/J and SM/J proteomic signature with a list of over 1000 matrisomal proteins generated by Naba and co-workers (33), we provide a first comprehensive comparison of NP IVD matrix composition in a good and bad condition and identify potential changes that are fundamental for maintenance of a healthy disc.
HostingRepository	PRIDE
AnnounceDate	2018-04-16
AnnouncementXML	Submission_2018-04-16_02:10:41.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	MATEUSZ KUDELKO
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-29 03:06:01	ID requested
⏵ 1	2018-04-16 02:10:42	announced

Zhang Y, Xiong C, Kudelko M, Li Y, Wang C, Wong YL, Tam V, Rai MF, Cheverud J, Lawson HA, Sandell L, Chan WCW, Cheah KSE, Sham PC, Chan D, Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events. Matrix Biol, 70():123-139(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Mouse intervertebral disc, proteomic, nucleus pulposus, LG/J and SM/J.

Professor Danny Chan
contact affiliation	S Y and H Y Cheng Professor in Stem Cell Biology and Regenerative Medicine Assistant Dean (Research postgraduate studies), Faculty of Medicine Professor (School of Biomedical Sciences), Faculty of Medicine Deputy Director (Education and Development of Research Integrity), HKU
contact email	chand@hku.hk
lab head
MATEUSZ KUDELKO
contact affiliation	HKU Biochemistry
contact email	mkudelko@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/04/PXD008784

PRIDE project URI

• PRIDE
  1. PXD008784
     1. Label: PRIDE project
     2. Name: SM/J mice display spontaneous early onset disc degeneration link to ion transport system and matrisome changes