PXD008778

PXD008778 is an original dataset announced via ProteomeXchange.

Title	p140Cap interactome in breast cancer cells
Description	Even though neuronal and cancer cells have quite different purposes in the body, there is growing evidence that metastatic cancer cells implement signaling mechanisms found in homeostasis of synaptic growth/plasticity. Recent studies have highlight some remarkable similarities in both form and function of these two unique cell type. The p140Cap adaptor protein is an example of a mo-lecular hub that controls cancer cell migration and invasion through regulating protein complexes at cellular adhesions. Moreover, p140Cap in neurons is likely very important for normal brain function-ing, as it works as scaffold in postsynaptic signal transmission complexes and regulates F-actin re-modelling, which results in neuron dendritic spines synaptic plasticity It recruits and regulates signaling molecules both in breast cancer cells and in healthy neuronal synapses.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:04:36.896.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yohann Couté
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-29 01:15:45	ID requested
1	2019-09-25 06:49:34	announced
2	2019-11-06 00:35:38	announced	2019-11-06: Updated publication reference for PubMed record(s): 31681758.
⏵ 3	2024-10-22 04:04:45	announced	2024-10-22: Updated project metadata.

Chapelle J, Sorokina O, McLean C, Salemme V, Alfieri A, Angelini C, Morellato A, Adrait A, Menna E, Matteoli M, Cout, é Y, Ala U, Turco E, Defilippi P, Armstrong JD, Dissecting the Shared and Context-Dependent Pathways Mediated by the p140Cap Adaptor Protein in Cancer and in Neurons. Front Cell Dev Biol, 7():222(2019) [pubmed]

10.3389/fcell.2019.00222;

curator keyword: Biological, Biomedical

submitter keyword: breast cancer, co-IP, nanoLC-MS/MS,p140Cap

Virginie Brun
contact affiliation	EDyP
contact email	virginie.brun@cea.fr
lab head
Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD008778

PRIDE project URI

• PRIDE
  1. PXD008778
     1. Label: PRIDE project
     2. Name: p140Cap interactome in breast cancer cells