⮝ Full datasets listing

PXD008778

PXD008778 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titlep140Cap interactome in breast cancer cells
DescriptionEven though neuronal and cancer cells have quite different purposes in the body, there is growing evidence that metastatic cancer cells implement signaling mechanisms found in homeostasis of synaptic growth/plasticity. Recent studies have highlight some remarkable similarities in both form and function of these two unique cell type. The p140Cap adaptor protein is an example of a mo-lecular hub that controls cancer cell migration and invasion through regulating protein complexes at cellular adhesions. Moreover, p140Cap in neurons is likely very important for normal brain function-ing, as it works as scaffold in postsynaptic signal transmission complexes and regulates F-actin re-modelling, which results in neuron dendritic spines synaptic plasticity It recruits and regulates signaling molecules both in breast cancer cells and in healthy neuronal synapses.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:04:36.896.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYohann Couté
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-01-29 01:15:45ID requested
12019-09-25 06:49:34announced
22019-11-06 00:35:38announced2019-11-06: Updated publication reference for PubMed record(s): 31681758.
32024-10-22 04:04:45announced2024-10-22: Updated project metadata.
Publication List
Chapelle J, Sorokina O, McLean C, Salemme V, Alfieri A, Angelini C, Morellato A, Adrait A, Menna E, Matteoli M, Cout, é Y, Ala U, Turco E, Defilippi P, Armstrong JD, Dissecting the Shared and Context-Dependent Pathways Mediated by the p140Cap Adaptor Protein in Cancer and in Neurons. Front Cell Dev Biol, 7():222(2019) [pubmed]
10.3389/fcell.2019.00222;
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: breast cancer, co-IP, nanoLC-MS/MS,p140Cap
Contact List
Virginie Brun
contact affiliationEDyP
contact emailvirginie.brun@cea.fr
lab head
Yohann Couté
contact affiliationEDyP
contact emailyohann.coute@cea.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD008778
PRIDE project URI
Repository Record List
[ + ]