PXD008736

PXD008736 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics profiling determines the uniqueness of the sinus node
Description	The sinus node is a collection of highly specialized cells that constitute the natural pacemaker activity of our heart. The protein expression landscape of the sinus node differs from the surrounding cardiac tissue, although it is primarily comprised of myocytes and fibroblasts like the rest of the cardiac tissue, endowing it with its unique ability to regulate heart rate. Here we performed quantitative proteomics experiments to profile protein expression in the pacemaker of the heart, and compared it to protein expression in the neighbouring atrial muscle. In summary, the quantitative proteomics data presented here offer a highly detailed insight into the unique composition of the pacemaker of our heart.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:04:12.844.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nora Linscheid
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-22 02:08:19	ID requested
1	2019-07-08 01:47:35	announced
2	2019-07-12 00:30:25	announced	Updated project metadata.
⏵ 3	2024-10-22 04:04:21	announced	2024-10-22: Updated project metadata.

Linscheid N, Logantha SJRJ, Poulsen PC, Zhang S, Schr, ö, lkamp M, Egerod KL, Thompson JJ, Kitmitto A, Galli G, Humphries MJ, Zhang H, Pers TH, Olsen JV, Boyett M, Lundby A, Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking. Nat Commun, 10(1):2889(2019) [pubmed]

10.1038/s41467-019-10709-9;

curator keyword: Biological

submitter keyword: pacemaker, heart, tissue,Sinus node, mouse, conduction, LC-MS/MS

Alicia Lundby
contact affiliation	Department of Biomedical Sciences & NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Noerre Allé 14, 9-07-34, DK-2200 Copenhagen N
contact email	alicia.lundby@sund.ku.dk
lab head
Nora Linscheid
contact affiliation	University of Copenhagen
contact email	hxz265@alumni.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD008736

PRIDE project URI

• PRIDE
  1. PXD008736
     1. Label: PRIDE project
     2. Name: Quantitative proteomics profiling determines the uniqueness of the sinus node