PXD008722

PXD008722 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics of human heart samples collected in vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation.
Description	Genetic and genomic research has greatly advanced our understanding of heart disease; yet a comprehensive map of the protein landscape of living human hearts is still lacking. Here we set out to identify the molecular basis of functional differences between human cardiac chambers by comprehensive protein expression quantification from samples collected in vivo by high-resolution mass spectrometry. Cardiac biopsies of right atria (RA), left atria (LA) and left ventricle (LV) were obtained from seven humans undergoing open chest surgery and analyzed by high-resolution mass spectrometry. We identify hundreds of proteins with a chamber specific expression pattern, supporting the different functional roles of the cardiac chambers, enabling identification of chamber specific drug targets, and offering novel links between genomic data and the mechanisms of disease.
HostingRepository	PRIDE
AnnounceDate	2020-06-15
AnnouncementXML	Submission_2020-06-15_03:48:38.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nora Linscheid
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-19 04:06:09	ID requested
⏵ 1	2020-06-15 03:48:39	announced

Linscheid N, Poulsen PC, Pedersen ID, Gregers E, Svendsen JH, Olesen MS, Olsen JV, Delmar M, Lundby A, Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation. Mol Cell Proteomics, 19(7):1132-1144(2020) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: human, heart, tissue, biopsies, mitral valve disease, dilated cardiomyopathy, hypertrophy, GWAS

Alicia Lundby
contact affiliation	Cardiac Proteomics, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
contact email	alicia.lundby@sund.ku.dk
lab head
Nora Linscheid
contact affiliation	University of Copenhagen
contact email	hxz265@alumni.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD008722

PRIDE project URI

• PRIDE
  1. PXD008722
     1. Label: PRIDE project
     2. Name: Quantitative proteomics of human heart samples collected in vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation.