PXD008720

PXD008720 is an original dataset announced via ProteomeXchange.

Title	Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging
Description	Mammals display wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, we compared the liver of long-lived naked mole-rats (NMRs) and the phylogenetically closely related, shorter-lived, guinea pigs using an integrated omic approach. We found that NMRs livers display a unique expression pattern of mitochondrial proteins that result in distinct metabolic features of their mitochondria. For instance, we observed a generally reduced respiration rate associated with lower protein levels of respiratory chain components, particularly complex I, and increased capacity to utilize fatty acids. Interestingly, we show that the same molecular networks are affected during aging in both NMR and humans, supporting a direct link to the extraordinary longevity of both species. Finally, we identified a novel longevity pathway and validated it experimentally in the nematode C. elegans.
HostingRepository	PRIDE
AnnounceDate	2018-06-21
AnnouncementXML	Submission_2019-02-26_07:58:56.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joanna Kirkpatrick
SpeciesList	scientific name: Heterocephalus glaber; NCBI TaxID: 10181; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Cavia porcellus (Guinea pig); NCBI TaxID: 10141;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-19 03:45:41	ID requested
1	2018-06-21 07:47:12	announced
⏵ 2	2019-02-26 07:58:57	announced	Updated publication reference for PubMed record(s): 30068331.

Heinze I, Bens M, Calzia E, Holtze S, Dakhovnik O, Sahm A, Kirkpatrick JM, Szafranski K, Romanov N, Sama SN, Holzer K, Singer S, Ermolaeva M, Platzer M, Hildebrandt T, Ori A, Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging. BMC Biol, 16(1):82(2018) [pubmed]

curator keyword: Biological

submitter keyword: Liver, naked mole-rat, longevity, human aging

Alessandro Ori
contact affiliation	Group leader - Systems Biology of Aging Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) Germany
contact email	alessandro.ori@leibniz-fli.de
lab head
Joanna Kirkpatrick
contact affiliation	Leibniz Institute on Aging - FLI
contact email	joanna.kirkpatrick@leibniz-fli.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD008720

PRIDE project URI

• PRIDE
  1. PXD008720
     1. Label: PRIDE project
     2. Name: Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging