PXD008713

PXD008713 is an original dataset announced via ProteomeXchange.

Title	Rapid proteomic workflow for solid tumors reveals LSD1 as a drug target in an end stage cancer patient
Description	Recent advances in mass spectrometry (MS)-based technologies are now set to transform translational cancer proteomics from an idea to a practice. Here, we present a robust proteomic workflow for the analysis of clinically relevant human cancer tissues, which allows quantitation of thousands of tumor proteins in several hours of measuring time and a total turnaround of a few days. We applied it to a chemorefractory metastatic case of the extremely rare urachal carcinoma. Quantitative comparison of lung metastases and surrounding tissue revealed several significantly upregulated proteins, among them lysine specific histone demethylase 1 (LSD1/KDM1A). LSD1 is an epigenetic regulator and is the target of active development efforts in oncology. This demonstrates that clinical cancer proteomics can rapidly and efficiently identify actionable therapeutic options. While currently described for a single case study, we envision that it can be applied broadly to other patients in a similar condition.
HostingRepository	PRIDE
AnnounceDate	2018-06-15
AnnouncementXML	Submission_2018-06-15_03:25:32.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-19 00:35:32	ID requested
⏵ 1	2018-06-15 03:25:33	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Proteomics, mass spectrometry, cancer

Prof. Matthias Mann
contact affiliation	Max Planck Institute of Biochemistry
contact email	mmann@biochem.mpg.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD008713
     1. Label: PRIDE project
     2. Name: Rapid proteomic workflow for solid tumors reveals LSD1 as a drug target in an end stage cancer patient