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PXD008710

PXD008710 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNeurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology.
DescriptionSpinal Muscular Atrophy (SMA) is an inherited neurodegenerative condition caused by reduction in functional Survival Motor Neurones Protein (SMN). SMN has been implicated in transport of mRNA in neural cells for local translation. We previously identified microtubule-dependant mobile vesicles rich in SMN and SmB, a member of the Sm family of snRNP-associated proteins, in neural cells. By comparing the interactomes of SmB and SmN, a neural-specific Sm protein, we now show that the essential neural protein neurochondrin (NCDN) interacts with Sm proteins and SMN in the context of mobile vesicles in neurites. NCDN has roles in protein localisation in neural cells, and in maintenance of cell polarity. NCDN is required for the correct localisation of SMN, suggesting they may both be required for formation and transport of trafficking vesicles. NCDN may have potential as a therapeutic target for SMA together with, or in place of, those targeting SMN expression
HostingRepositoryPRIDE
AnnounceDate2018-04-25
AnnouncementXMLSubmission_2018-04-25_00:30:18.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSally Shirran
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-01-18 03:38:56ID requested
12018-03-15 08:36:55announced
22018-04-25 00:30:19announcedUpdated project metadata.
Publication List
Thompson LW, Morrison KD, Shirran SL, Groen EJN, Gillingwater TH, Botting CH, Sleeman JE, Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology. J Cell Sci, 131(8):(2018) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Spinal Muscular Atrophy, Neurochondrin, SMN, Sm Proteins, snRNPs
Contact List
Judith Elizabeth Sleeman
contact affiliationJudith Sleeman PhD FRSB Lecturer in Developmental Cell Biology BSRC Complex School of Biology University of St Andrews KY16 9ST UK +44 (0)1334 463524
contact emailjes14@st-andrews.ac.uk
lab head
Sally Shirran
contact affiliationUniversity of St Andrews
contact emailss101@st-andrews.ac.uk
dataset submitter
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