PXD008705

PXD008705 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	DiPIUS_Fbxw7
Description	Although elucidation of enzyme–substrate relations is fundamental to the advancement of biology, universal approaches to the identification of substrates for a given enzyme have not been established. It is especially difficult to identify substrates for ubiquitin ligases, given that most such substrates are immediately ubiquitylated and degraded as a result of their association with the enzyme. We here describe the development of a new approach, DiPIUS (differential proteomics-based identification of ubiquitylation substrates), to the discovery of substrates for ubiquitin ligases. We applied DiPIUS to Fbxw7α, and identified candidate substrates including previously known targets. DiPIUS is thus a powerful tool for unbiased and comprehensive screening for substrates of ubiquitin ligases.
HostingRepository	jPOST
AnnounceDate	2018-03-06
AnnouncementXML	Submission_2022-09-18_03:39:01.838.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kanae Yumimoto
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; 2-pyrrolidone-5-carboxylic acid (Gln)
Instrument	LTQ

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-17 17:14:06	ID requested
1	2018-03-06 00:35:30	announced
2	2018-09-19 00:45:36	announced	Updated CV, FTP location and Modification list.
3	2021-02-04 17:00:45	announced	2021-02-04: Updated FTP location.
⏵ 4	2022-09-18 03:39:02	announced	2022-09-18: Updated FTP location.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: substrates, Fbxw7, ubiquitin ligase

submitter keyword: substrates, Fbxw7, ubiquitin ligase

Contact List

Keiichi I. Nakayama
lab head
Kanae Yumimoto
contact affiliation	Kyushu University
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000373/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000373/