PXD008642

PXD008642 is an original dataset announced via ProteomeXchange.

Title	Human breast cancer cell line and tissue, ISE-affinity proteogenomics
Description	Introducing a clinical-practical, alternative splicing activity-based proteogenomic method that identifies, in their oncogenically active states, biomarker genes bearing patient-specific GE or copy-number alterations of prognostic significance. This integrated multi-omics method uses intronic splicing enhancers (ISEs) probes to sort in situ ISE-interacting trans-acting protein factors (trans-interactome) directly from a heterogeneous tumor for subsequent mass spectrometry (MS) characterization.
HostingRepository	PRIDE
AnnounceDate	2018-03-20
AnnouncementXML	Submission_2018-03-20_01:14:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Li Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	6x(13)C labeled L-lysine; 6x(13)C: 4x(15)N labeled L-arginine; 6x(13)C: 2x(15)N labeled L-lysine; monohydroxylated residue; iodoacetamide derivatized residue; 6x(13)C labeled L-arginine
Instrument	LTQ Orbitrap Velos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-10 01:21:43	ID requested
⏵ 1	2018-03-20 01:14:19	announced

Wang L, Wrobel JA, Xie L, Li D, Zurlo G, Shen H, Yang P, Wang Z, Peng Y, Gunawardena HP, Zhang Q, Chen X, Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer. Cell Chem Biol, 25(5):619-633.e5(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: ISE-Affinity proteomics, precision marker, ISE trans-interactomes

Xian Chen
contact affiliation	Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill,NC 27599,USA
contact email	liwang@email.unc.edu
lab head
Li Wang
contact affiliation	Postdoctoral Research Associate
contact email	liwang@email.unc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/03/PXD008642

PRIDE project URI

• PRIDE
  1. PXD008642
     1. Label: PRIDE project
     2. Name: Human breast cancer cell line and tissue, ISE-affinity proteogenomics