PXD008637

PXD008637 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Multiplexed proteome dynamics profiling of JQ1-PROTAC
Description	Goal of this experiment was the differentiation of direct targets of induced degradation of the JQ1-PROTAC from downstream regulatory effects.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:07:31.259.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maria Faelth Savitski
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; 6x(13)C; methionine oxidation with neutral loss of 64 Da; 6x(13)C; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-09 08:20:30	ID requested
1	2018-05-02 04:36:02	announced
⏵ 2	2024-10-22 04:07:32	announced	2024-10-22: Updated project metadata.

Publication List

Savitski MM, Zinn N, Faelth-Savitski M, Poeckel D, Gade S, Becher I, Muelbaier M, Wagner AJ, Strohmer K, Werner T, Melchert S, Petretich M, Rutkowska A, Vappiani J, Franken H, Steidel M, Sweetman GM, Gilan O, Lam EYN, Dawson MA, Prinjha RK, Grandi P, Bergamini G, Bantscheff M, Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis. Cell, 173(1):260-274.e25(2018) [pubmed]
10.1016/j.cell.2018.02.030;

Savitski MM, Zinn N, Faelth-Savitski M, Poeckel D, Gade S, Becher I, Muelbaier M, Wagner AJ, Strohmer K, Werner T, Melchert S, Petretich M, Rutkowska A, Vappiani J, Franken H, Steidel M, Sweetman GM, Gilan O, Lam EYN, Dawson MA, Prinjha RK, Grandi P, Bergamini G, Bantscheff M, Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis. Cell, 173(1):260-274.e25(2018) [pubmed]

10.1016/j.cell.2018.02.030;

Keyword List

curator keyword: Biomedical
submitter keyword: VHL, PROTAC, mPDP,JQ1

curator keyword: Biomedical

submitter keyword: VHL, PROTAC, mPDP,JQ1

Contact List

Marcus Bantscheff
contact affiliation	Cellzome
contact email	marcus.x.bantscheff@gsk.com
lab head
Maria Faelth Savitski
contact affiliation	Cellzome
contact email	maria.x.faelth-savitski@gsk.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD008637
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD008637

PRIDE project URI

Repository Record List

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