PXD008623

PXD008623 is an original dataset announced via ProteomeXchange.

Title	Comparative proteomic analysis revealed complex responses to classical/novel duck reovirus infections in Cairna moschata
Description	Duck reovirus (DRV) is an typical aquatic bird pathogen belonging to the Orthoreovirus genus of the Reoviridae family. Reovirus causes a fatal disease resulting to huge economic losses to the duck industry. Although DRV has been identified and isolated long ago, the responses of Cairna moschata to classical/novel duck reovirus (CDRV/NDRV) infections are largely unknown. Using an integrated approach involving TMT labeling and LC-MS/MS analysis, proteomes of C. moschata liver cells under C/NDRV infections were analyzed. In total, 5571 proteins were identified, among which 5015 proteins were quantified. The differential expressed proteins (DEPs) between the control and infected liver cells displayed various biological functions and diverse subcellular localizations. Among the DEPs, most of the metabolism-related proteins were down-regulated, suggesting a decrease in the basal metabolisms under C/NDRV infections. Several important factors in the complement, coagulation and fibrinolytic systems were significantly up-regulated by C/NDRV infections, indicating that the serine protease-mediated innate immune system may play roles in the responses to C/NDRV infections. Moreover, a number of molecular chaperones were identified, and no significantly changes in their abundances were observed in the liver cells. Our data may give a comprehensive resource for investigating the regulation mechanism involved in the responses to C/NDRV infections in C. moschata.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:06:27.522.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rachel Green
SpeciesList	scientific name: Cairina moschata; NCBI TaxID: 8855;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-09 03:55:24	ID requested
1	2018-10-22 09:11:24	announced
2	2020-08-22 16:48:10	announced	2020-08-23: Updated publication reference for PubMed record(s): 29973707, 32820866.
⏵ 3	2024-10-22 04:06:43	announced	2024-10-22: Updated project metadata.

Xiao C, Huang Y, Wei Q, Liu Y, Ji Q, Li K, Bao G, Comparative Proteomic Analysis Reveals Complex Responses to Bordetella bronchiseptica Infections in the Spleen of Rabbits. Proteomics, 20(24):e2000117(2020) [pubmed]

10.1038/s41598-018-28499-3;

10.1002/pmic.202000117;

Yun T, Hua J, Ye W, Yu B, Chen L, Ni Z, Zhang C, Comparative proteomic analysis revealed complex responses to classical/novel duck reovirus infections in Cairna moschata. Sci Rep, 8(1):10079(2018) [pubmed]

curator keyword: Biological

submitter keyword: Cairna moschata

differential expressed protein

duck reovirus

proteome

serine protease

Cun Zhang
contact affiliation	Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences
contact email	zhangcun@aliyun.com
lab head
Rachel Green
contact affiliation	PTM Biolabs Inc.
contact email	xuan_mao@ptm-biolab.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD008623
     1. Label: PRIDE project
     2. Name: Comparative proteomic analysis revealed complex responses to classical/novel duck reovirus infections in Cairna moschata