PXD008613

PXD008613 is an original dataset announced via ProteomeXchange.

Title	Malaria Hepatocyte HC-04.J7 Project
Description	Characterization of three hepatocyte cell lines (2 parental and 1 clone), under two different media conditions. Parental cell lines HepG2 and HC-04, single cell cloned from HC-04 defined as HC-04.J7. The goal of the project initially was to investigate the invasion of hepatocytes by Plasmodium falciparum sporozoites, and once found that the HC-04 cell had a higher invasion than HepG2, single cell isolates were generated from HC-04 before being expanded. The resulting HC-04.J7 isolate further improved the invasion rate. Transcriptomic and proteomic data sets were generated from all cell lines in both media, than analyzed for potential receptors or biochemical pathways that play a role in the increased invasion of HC-04 and specifically, HC-04.J7.
HostingRepository	PRIDE
AnnounceDate	2019-11-12
AnnouncementXML	Submission_2019-11-12_10:33:04.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD008613
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Timothy Hamerly
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Ammonia-loss; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
Instrument	6220 Time-of-Flight LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-08 07:33:26	ID requested
⏵ 1	2019-11-12 10:33:06	announced

Tweedell RE, Tao D, Hamerly T, Robinson TM, Larsen S, Gr, ø, nning AGB, Norris AM, King JG, Law HCH, Baumbach J, Bergmann-Leitner ES, Dinglasan RR, Sporozoite Invasion That Is Associated With Expression of Glypican-3. Front Microbiol, 10():127(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Malaria, Plasmodium falciparum, Human Liver, Hepatocyte, LC-MS/MS

Rhoel David Ramos Dinglasan
contact affiliation	Department of Infectious Diseases and Immunology, Emerging Pathogens Institute, University of Florida, United States of America
contact email	rdinglasan@epi.ufl.edu
lab head
Timothy Hamerly
contact affiliation	Rhoel Dinglasan Lab, University of Florida
contact email	timothy.hamerly@ufl.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD008613

PRIDE project URI

• PRIDE
  1. PXD008613
     1. Label: PRIDE project
     2. Name: Malaria Hepatocyte HC-04.J7 Project