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PXD008606

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2018-01-12
  • AnnouncementXML: Submission_2018-01-12_05:24:34.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Praveen Sappa
  • Title: BCL11B_AP-MS
  • Description: This study investigates whether the N-terminal CCHC zinc finger motif is necessary and sufficient for the formation of BCL11B dimers, using fluorescence microscopy and Förster resonance energy transfer-assisted fluorescence-activated cell sorting (FACSFRET). The role of the CCHC motif in homodimer assembly was further investigated using affinity purification followed by mass spectrometry (AP-MS). Functional studies investigated the role of dimerization in the induction of cell cycle arrest and protection against DNA damage-induced apoptosis.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: monohydroxylated residue; iodoacetamide derivatized residue
  • Instrument: TSQ Vantage; Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02018-01-08 00:19:52ID requested
12018-01-12 05:24:35announced

Publication List

  1. Grabarczyk P, Winkler P, Delin M, Sappa PK, Bekeschus S, Hildebrandt P, Przybylski GK, Völker U, Hammer E, Schmidt CA, The N-Terminal CCHC Zinc Finger Motif Mediates Homodimerization of Transcription Factor BCL11B. Mol Cell Biol, 38(5):(2018) [pubmed]

Keyword List

  1. ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
  2. curator keyword: Biological
  3. submitter keyword: AP-MS, Co-immuno precipitation, LC-MS/MS, SRM, PPIN

Contact List

    Christian Schmidt
    • contact affiliation: komm. Direktor for Innere Medizin mit Schwerpunktbezeichnung Hämatologie und internistische Onkologie, Universitätsmedizin Greifswald.
    • contact email: caschmid@uni-greifswald.de
    • lab head:
    Praveen Sappa
    • contact affiliation: Universitätsmedizin Greifswald
    • contact email: praveen.kumar@uni-greifswald.de
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List
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