PXD008600

PXD008600 is an original dataset announced via ProteomeXchange.

Title	Proteomics of Human Cervical Mucus Plugs
Description	Preterm birth is a leading cause of neonatal mortality and lacks an effective therapy. Ascending microbial infections from the lower genital tract lead to infection of the placenta, amniotic fluid and fetus causing preterm birth or stillbirth. Directly in the path of an ascending infection is the cervical mucus plug (CMP), a dense mucoid structure in the cervical canal with potential antimicrobial properties. In this study, we aimed to define the components of CMP responsible for antimicrobial activity against a common lower genital tract organism associated with preterm birth and stillbirths, namely Group B Streptococcus (GBS). Using a quantitative proteomic approach, we identified antimicrobial factors in CMPs that were collected from healthy human pregnancies. This study aims to provide new insight into how the human CMP may limit ascending bacterial infection.
HostingRepository	PRIDE
AnnounceDate	2019-10-10
AnnouncementXML	Submission_2019-10-11_03:03:47.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Philip Gafken
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	methylthiolated residue; monohydroxylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-05 01:54:16	ID requested
1	2018-02-09 09:17:24	announced
2	2019-10-10 08:52:55	announced	2019-10-10: Updated project metadata.
⏵ 3	2019-10-11 03:03:49	announced	2019-10-10: Updated project metadata. 2019-10-11: Updated publication reference for PubMed record(s): 29425317.

Vornhagen J, Quach P, Santana-Ufret V, Alishetti V, Brokaw A, Armistead B, Qing Tang H, MacDonald JW, Bammler TK, Adams Waldorf KM, Uldbjerg N, Rajagopal L, Human Cervical Mucus Plugs Exhibit Insufficiencies in Antimicrobial Activity Towards Group B Streptococcus. J Infect Dis, 217(10):1626-1636(2018) [pubmed]

curator keyword: Biological

submitter keyword: Cervical Mucus Plugs, Human, Mass Spectrometry, proteomics, proteins, peptides, antimicrobial

Lakshmi Rajagopal, Ph.D
contact affiliation	Associate Professor, Pediatrics Adjunct Associate Professor, Microbiology and Global Health Affiliate Member: FHCRC Consortium University of Washington Seattle Childrens Research Institute 1900 9th Ave SeattleWA 98101-1304
contact email	Lakshmi.rajagopal@seattlechildrens.org
lab head
Philip Gafken
contact affiliation	Fred Hutchinson Cancer Research Center
contact email	pgafken@fhcrc.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD008600

PRIDE project URI

• PRIDE
  1. PXD008600
     1. Label: PRIDE project
     2. Name: Proteomics of Human Cervical Mucus Plugs