PXD008568

PXD008568 is an original dataset announced via ProteomeXchange.

Title	Human plasma LC-MSMS
Description	Patent ductus arteriosus (PDA) is the third most common congenital heart disease and resulted from the persistence of ductal patency after birth. Ductus arteriosus closure involves functional and structural remodeling, controlled by many factors. The closure-related human plasma proteins are unknown. Here we for the first time demonstrate six key differential plasma proteins in the human PDA patients using proteomic technology and present a model to illustrate the constriction and closure of ductus arteriosus. We found that permanent closure might be regulated by the proteins related to platelet activation and coagulation cascades, complement mannan-binding-lectin, and other systemic signaling pathways. Our findings indicate that the differential proteins involved in these pathways may play key roles in the non-closure of the ductus arteriosus and may be developed as biomarkers for diagnosis. All those findings may be served as the basis of understanding the etiology and pathogenesis of PDA.
HostingRepository	PRIDE
AnnounceDate	2018-11-30
AnnouncementXML	Submission_2018-12-04_08:14:10.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hai-Tao Hou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-02 02:28:03	ID requested
1	2018-11-30 05:10:31	announced
⏵ 2	2018-12-04 08:14:12	announced	Updated publication reference for PubMed record(s): 30480800.

Hou HT, Xi-Zhang, Wang J, Liu LX, Zhang JF, Yang Q, He GW, Altered plasma proteins released from platelets and endothelial cells are associated with human patent ductus arteriosus. J Cell Physiol, 234(5):6842-6853(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Human,Patent ductus arteriosus, Plasma, Proteomics,LC-MSMS

Hai-Tao Hou
contact affiliation	Department of basic research center,TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
contact email	hhtpk007@163.com
lab head
Hai-Tao Hou
contact affiliation	Teda International Cardiovascular Hospital
contact email	hhtpk007@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD008568

PRIDE project URI

• PRIDE
  1. PXD008568
     1. Label: PRIDE project
     2. Name: Human plasma LC-MSMS