PXD008553

PXD008553 is an original dataset announced via ProteomeXchange.

Title	Serum proteomic pattern in female stress urinary incontinence
Description	The pathophysiology of Stress Urinary Incontinence (SUI) is poorly understood. The aim of this study was to identify the serum proteomic profile in patients with SUI and to replicate findings from a preceding study in which a significant difference in the urinary proteome was identified. Serum samples were collected from 38 patients (19 SUI; 19 matched, continent controls). Sample preparation included serum albumin depletion, in-solution enzymatic digestion of proteins applying a combination of Gluc-C and trypsin and peptide separation using nano High Performance Liquid Chromatography. Label-free quantitation of peptides and proteins was performed after triplicate measurements using quadrupole time-of-flight mass spectrometry. Peptide identification was achieved by searching the Human SwissProt Database using Mascot and X!Tandem. Main outcome measure was the relative abundance of each detected protein in serum.
HostingRepository	PRIDE
AnnounceDate	2018-01-24
AnnouncementXML	Submission_2018-01-24_10:58:03.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD008553
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Goran Mitulović
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Ammonia-loss; Phospho; Deamidated; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-22 06:12:12	ID requested
⏵ 1	2018-01-24 10:58:04	announced

Koch M, Umek W, Hanzal E, Mohr T, Seyfert S, Koelbl H, Mitulovi, ć G, Serum proteomic pattern in female stress urinary incontinence. Electrophoresis, 39(8):1071-1078(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Stress, Urinary incotinence, proteomics, serum, female

Goran Mitulović
contact affiliation	Medical University of Vienna Clinical Department of Laboratory Medicine Proteomics Core Facility, E5, LS5H Waehringer Guertel 18-20 A-1090 Wien, Austria
contact email	goran.mitulovic@meduniwien.ac.at
lab head
Goran Mitulović
contact affiliation	Medizinische Universität Wien
contact email	goran.mitulovic@meduniwien.ac.at
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD008553
     1. Label: PRIDE project
     2. Name: Serum proteomic pattern in female stress urinary incontinence