PXD008517

PXD008517 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station
Description	The on-going Microbial Observatory Experiments on the International Space Station (ISS) revealed the presence of various microorganisms that may be affected by the distinct environment of the ISS. The low-nutrient environment combined with enhanced irradiation and microgravity may trigger changes in the molecular suit of microorganisms leading to increased virulence and resistance of microbes. Proteomic characterization of two Aspergillus fumigatus strains, ISSFT-021 and IF1SW-F4, isolated from HEPA filter debris and cupola surface of the ISS, respectively, is presented, along with a comparison to experimentally established clinical isolates Af293 and CEA10. In-depth analysis highlights variations in the proteome of both ISS-isolated strains when compared to the clinical strains. Proteins up-regulated in ISS isolates were involved in oxidative stress response, and carbohydrate and secondary metabolism. This report provides insight into possible molecular adaptation of filamentous fungi to the unique ISS environment. Lastly, an attempt was made to elucidate plausible causes of the enhanced virulence of both ISS-isolated A. fumigatus strains.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:13:15.924.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Abby Chiang
SpeciesList	scientific name: Aspergillus fumigatus Af293; NCBI TaxID: 330879;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-20 02:22:02	ID requested
1	2019-01-09 02:22:58	announced
⏵ 2	2024-10-22 04:13:23	announced	2024-10-22: Updated project metadata.

10.1016/j.fgb.2019.01.001;

Blachowicz A, Chiang AJ, Romsdahl J, Kalkum M, Wang CCC, Venkateswaran K, Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station. Fungal Genet Biol, 124():39-46(2019) [pubmed]

curator keyword: Biological

submitter keyword: Aspergillus fumigatus,Proteomic, International Space Station

Markus Kalkum
contact affiliation	Beckman Research Institute of City of Hope
contact email	mkalkum@coh.org
lab head
Abby Chiang
contact affiliation	City of Hope
contact email	jchiang@coh.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/01/PXD008517

PRIDE project URI

• PRIDE
  1. PXD008517
     1. Label: PRIDE project
     2. Name: Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station