PXD008488
PXD008488 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative salivary proteomics analysis of children with and without dental caries using the iTRAQ/MRM approach |
| Description | In this study, unstimulated saliva samples were collected from 30 children (age 10-12 years) with no dental caries (NDC, n=10), low dental caries (LDC, n=10), and high dental caries (HDC, n=10). Salivary proteins were extracted, reduced, alkylated, trypsin digested and labeled with isobaric tags for relative and absolute quantitation (iTRAQ), and then they were analyzed with GO annotation, biological pathway analysis, hierarchical clustering analysis, and protein-protein interaction analysis. Targeted verifications were then performed using multiple reaction monitoring mass spectrometry (MRM-MS). |
| HostingRepository | iProX |
| AnnounceDate | 2017-12-19 |
| AnnouncementXML | Submission_2019-12-12_19:58:34.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kun Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | iTRAQ8plex reporter+balance reagent acylated residue |
| Instrument | Q Exactive; QTRAP 6500+; TripleTOF 6600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2017-12-18 22:01:19 | ID requested | |
| 1 | 2017-12-18 22:01:32 | announced | |
| 2 | 2017-12-19 00:51:21 | announced | Update keyword information. |
| ⏵ 3 | 2019-12-12 19:58:36 | announced | 2019-12-13: Update publication information. |
Publication List
| Wang K, Wang Y, Wang X, Ren Q, Han S, Ding L, Li Z, Zhou X, Li W, Zhang L, Comparative salivary proteomics analysis of children with and without dental caries using the iTRAQ/MRM approach. J Transl Med, 16(1):11(2018) [pubmed] |
Keyword List
| submitter keyword: Dental caries, children, salivary proteome, iTRAQ, MRM |
Contact List
| Linglin Zhang | |
|---|---|
| contact affiliation | State Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Dept. of Cariology and Endodontics West China Hospital of Stomatology, Sichuan University |
| contact email | zhll_sc@163.com |
| lab head | |
| Kun Wang | |
| contact affiliation | State Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Dept. of Cariology and Endodontics West China Hospital of Stomatology, Sichuan University |
| contact email | 806432676@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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