PXD008462

PXD008462 is an original dataset announced via ProteomeXchange.

Title	Human Retina Proteomics
Description	Differences in regional protein expression within the human retina may explain molecular predisposition of specific regions to ophthalmic diseases like age-related macular degeneration, cystoid macular edema, retinitis pigmentosa, and diabetic retinopathy. To quantify protein levels in the human retina and identify patterns of differentially-expressed proteins, we collected foveal, macular, and peripheral retina punch biopsies from healthy donor eyes and analyzed protein content by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
HostingRepository	PRIDE
AnnounceDate	2018-02-26
AnnouncementXML	Submission_2018-02-26_07:06:30.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vinit Mahajan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized amino-terminal residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-15 01:11:39	ID requested
⏵ 1	2018-02-26 07:06:31	announced

Velez G, Machlab DA, Tang PH, Sun Y, Tsang SH, Bassuk AG, Mahajan VB, Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases. PLoS One, 13(2):e0193250(2018) [pubmed]

Cabral T, Toral MA, Velez G, DiCarlo JE, Gore AM, Mahajan M, Tsang SH, Bassuk AG, Mahajan VB, Dissection of Human Retina and RPE-Choroid for Proteomic Analysis. J Vis Exp, (129):(2017) [pubmed]

curator keyword: Biological

submitter keyword: Retina, precision medicine, proteomics, biomarker, oxidative stress, metabolism, retinal degeneration

Vinit Mahajan
contact affiliation	Vinit B. Mahajan M.D., Ph.D., Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, 94304 USA (vinit.mahajan@stanford.edu). Phone: 650.723.6995. Fax: 650.498.1528.
contact email	vinit.mahajan@stanford.edu
lab head
Vinit Mahajan
contact affiliation	Stanford University
contact email	vinit.mahajan@stanford.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD008462

PRIDE project URI

• PRIDE
  1. PXD008462
     1. Label: PRIDE project
     2. Name: Human Retina Proteomics