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PXD008452

PXD008452 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMonocyte responses to Al(OH)3 adjuvant
DescriptionMonocytes, derived from three different donors, were stimulated with the vaccine adjuvant Al(OH)3 for 24 and 48 hours. Proteins were isolated and equal protein amounts were labeledusing TMT(6). We found that Al(OH)3 activates various pathways related to the innate immune response.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:42:07.893.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSietske Kooijman
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-12-14 03:22:06ID requested
12018-03-27 00:30:51announced
22018-03-27 02:57:57announcedUpdated project metadata.
32024-10-22 04:42:15announced2024-10-22: Updated project metadata.
Publication List
10.1016/j.jprot.2017.12.021;
Kooijman S, Brummelman J, van Els CACM, Marino F, Heck AJR, Mommen GPM, Metz B, Kersten GFA, Pennings JLA, Meiring HD, Novel identified aluminum hydroxide-induced pathways prove monocyte activation and pro-inflammatory preparedness. J Proteomics, 175():144-155(2018) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: alum-based adjuvant, innate immune response, quantitative proteomics
Contact List
Hugo Meiring
contact affiliationIntravacc; Bilthoven; the Netherlands
contact emailhugo.meiring@intravacc.nl
lab head
Sietske Kooijman
contact affiliationIntravacc
contact emailsietske.kooijman@intravacc.nl
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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