PXD008451

PXD008451 is an original dataset announced via ProteomeXchange.

Title	Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis
Description	Successful completion of cytokinesis requires the coordinated activities of diverse cellular components including membranes, cytoskeletal elements and chromosomes. Biochemical analysis of cytokinesis is challenging due to its dynamic and rapid nature that necessitates the establishment of robust methodologies. Our comparative proteomic approach suggests that monopolar cytokinesis is a good surrogate for cytokinesis and it is a well-suited system for global biochemical analysis in mammalian cells. We established a phosphoproteomic signature of cytokinesis. More than 10,000 phosphorylation sites were systematically screened and monitored; around 800 of these phosphosites were up-regulated during cytokinesis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:42:12.715.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Erdem Sanal
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-14 03:21:44	ID requested
1	2018-02-28 05:06:08	announced
2	2019-02-26 08:08:08	announced	Updated publication reference for PubMed record(s): 29396449.
⏵ 3	2024-10-22 04:42:13	announced	2024-10-22: Updated project metadata.

10.1038/s41598-018-20231-5;

Karayel Ö, Ş, anal E, Giese SH, Ü, retmen Kag, ı, al, ı ZC, Polat AN, Hu CK, Renard BY, Tuncbag N, Ö, zl, ü N, Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep, 8(1):2269(2018) [pubmed]

curator keyword: Biological

submitter keyword: cytokinesis, monopolar cytokinesis,Phosphoproteome, cell cycle

Nurhan Özlü
contact affiliation	Department of Molecular Biology and Genetics Koç University Istanbul, Turkey
contact email	nozlu@ku.edu.tr
lab head
Erdem Sanal
contact affiliation	Koc University
contact email	esanal14@ku.edu.tr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD008451

PRIDE project URI

• PRIDE
  1. PXD008451
     1. Label: PRIDE project
     2. Name: Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis