PXD008436

PXD008436 is an original dataset announced via ProteomeXchange.

Title	Predicting response to chemotherapy in rectal cancer
Description	Neoadjuvant chemoradiotherapy (CRT) is used in locally advanced rectal cancer when tumours threaten the circumferential resection margin. A variable response to treatment remains, notwithstanding potentially significant morbidity, and no clinically routinely used predictive biomarkers guide decision making. This experimental study aimed to identify significantly differentially expressed proteins between patients responding or not to CRT, using novel temporal proteomic profiling, and to validate any proteins of interest.
HostingRepository	PRIDE
AnnounceDate	2018-03-12
AnnouncementXML	Submission_2018-03-12_02:28:27.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rosalind Jenkins
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	dihydroxylated residue; amidated residue; methylthiolated residue; dehydrated residue; phosphorylated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue; formylated residue; monohydroxylated residue; acetylated residue; deamidated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-13 03:23:10	ID requested
⏵ 1	2018-03-12 02:28:28	announced

Bowden DL, Sutton PA, Wall MA, Jithesh PV, Jenkins RE, Palmer DH, Goldring CE, Parsons JL, Park BK, Kitteringham NR, Vimalachandran D, Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. J Proteomics, 179():53-60(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Rectal, cancer, chemoradiotherapy, response, proteomics, biomarker

Rosalind Elspeth Jenkins
contact affiliation	Proteomics Facility, Centre for Drug Safety Science, Dept Molecular and Clinical Pharmacology, University of Liverpool
contact email	R.Jenkins@liv.ac.uk
lab head
Rosalind Jenkins
contact affiliation	University of Liverpool
contact email	R.Jenkins@liv.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/03/PXD008436

PRIDE project URI

• PRIDE
  1. PXD008436
     1. Label: PRIDE project
     2. Name: Predicting response to chemotherapy in rectal cancer