PXD008430

PXD008430 is an original dataset announced via ProteomeXchange.

Title	Cell type resolved liver proteomics
Description	Parenchymatous organs consist of multiple cell types, primarily defined as parenchymal cells (PCs) and nonparenchymal cells (NPCs). The cellular characteristics of these organs are not well understood. Proteomic studies facilitate the resolution of the molecular details of different cell types in organs. These studies have significantly extended our knowledge about organogenesis and organ cellular composition. Here, we present an atlas of the cell-type-resolved liver proteome. In-depth proteomics identified 6000 to 8000 gene products (GPs) for each cell type and a total of 10,075 GPs for four cell types. This data set revealed features of the cellular composition of the liver: (1) hepatocytes (PCs) express the least GPs, have a unique but highly homogenous proteome pattern, and execute fundamental liver functions; (2) the division of labor among PCs and NPCs follows a model in which PCs make the main components of pathways, but NPCs trigger the pathways; and (3) crosstalk among NPCs and PCs maintains the PC phenotype. This study presents the liver proteome at cell resolution, serving as a research model for dissecting the cell type constitution and organ features at the molecular level.
HostingRepository	iProX
AnnounceDate	2017-04-20
AnnouncementXML	Submission_2017-12-14_22:55:00.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Feifei Guo
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-13 00:16:23	ID requested
1	2017-12-13 20:39:57	announced
⏵ 2	2017-12-14 22:55:02	announced	Update experiment information.

Ding C, Li Y, Guo F, Jiang Y, Ying W, Li D, Yang D, Xia X, Liu W, Zhao Y, He Y, Li X, Sun W, Liu Q, Song L, Zhen B, Zhang P, Qian X, Qin J, He F, A Cell-type-resolved Liver Proteome. Mol Cell Proteomics, 15(10):3190-3202(2016) [pubmed]

submitter keyword: liver, proteome

Xiaohong Qian
contact affiliation	National Center for Protein Sciences Beijing
contact email	qianxh1@163.com
lab head
Feifei Guo
contact affiliation	National Center for Protein Sciences Beijing
contact email	guofeifei434881733@126.com
dataset submitter

iProX dataset URI