PXD008419

PXD008419 is an original dataset announced via ProteomeXchange.

Title	Correction of cognitive deficits in mouse models of Down syndrome by pharmacological inhibitor of DYRK1A
Description	Down Syndrome (DS) results from the trisomy of human chromosome 21 (HSA21). It is still the most frequent intellectual disability, affecting 1 newborn per 700 births. Among candidate genes explaining intellectual disabilities seen in DS patients, the dual specificity tyrosine-phosphorylation regulated kinase 1A, DYRK1A, is located in the DS critical region of chromosome 21. DYRK1A has become a major screening target for the development of selective and potent pharmacological inhibitors. We here investigated the effects of a relatively selective DYRK1A inhibitor, Leucettine 41 (hereafter L41) in three different trisomic mouse models with increasing genetic complexity, Tg(Dyrk1a), Ts65Dn and Dp1Yey. Leucettines are derived from the marine sponge alkaloid Leucettamine B.
HostingRepository	PRIDE
AnnounceDate	2018-10-17
AnnouncementXML	Submission_2019-02-26_08:08:52.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antigoni Manousopoulou
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	methylthiolated residue; phosphorylated residue; monohydroxylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-12 02:01:03	ID requested
1	2018-10-17 08:23:43	announced
⏵ 2	2019-02-26 08:08:53	announced	Updated publication reference for PubMed record(s): 30115750.

Nguyen TL, Duchon A, Manousopoulou A, Loa, ë, c N, Villiers B, Pani G, Karatas M, Mechling AE, Harsan LA, Limanton E, Bazureau JP, Carreaux F, Garbis SD, Meijer L, Herault Y, Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A. Dis Model Mech, 11(9):(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: DYRK1A, Kinase inhibitor, Leucettine, Down syndrome, Synapsin

Spiros D Garbis
contact affiliation	University of Southampton
contact email	sdg2e11@soton.ac.uk
lab head
Antigoni Manousopoulou
contact affiliation	University of Southampton
contact email	am3v13@soton.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD008419

PRIDE project URI

• PRIDE
  1. PXD008419
     1. Label: PRIDE project
     2. Name: Correction of cognitive deficits in mouse models of Down syndrome by pharmacological inhibitor of DYRK1A