PXD008412

PXD008412 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics of the 2016 WHO Neisseria gonorrhoeae reference strains identifies vaccine candidates and antimicrobial resistance signatures.
Description	Neisseria gonorrhoeae is the causative agent of gonorrhea, a leading sexually transmitted disease with severe complications on reproductive health. The U.S. Centers for Disease Control and Prevention has categorized the public health threat induced by N. gonorrhoeae as “urgent”, due to the ease of transmission and the fast emergence of multi-drug resistant strains. The need for development of vaccines and understanding the underlying factors leading to antibiotic resistance is of utmost importance. The proteomic profiles of the 14 WHO N. gonorrhoeae reference strains have been compared to the WHO F reference strain using a mass spectrometry with tandem mass tags (TMT) labeling to analyze the cell envelope and the cytoplasmic fractions extracted from each strain. Identifying novel vaccine candidates and proteomic signatures for antimicrobial resistance will further our understanding of N. gonorrhoeae proteotypes, in relationship to their respective genotypes and phenotypes, and provide deep insights that will impact the development of preventive and therapeutic tools to combat gonorrhea.
HostingRepository	PRIDE
AnnounceDate	2018-12-19
AnnouncementXML	Submission_2018-12-19_08:08:39.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fadi El-Rami
SpeciesList	scientific name: Neisseria gonorrhoeae; NCBI TaxID: 485; scientific name: Neisseria gonorrhoeae FA6140; NCBI TaxID: 528353;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-11 06:05:18	ID requested
⏵ 1	2018-12-19 08:08:40	announced

El-Rami FE, Zielke RA, Wi T, Sikora AE, Unemo M, Reference Strains Surveys Vaccine Candidates and Antimicrobial Resistance Determinants. Mol Cell Proteomics, 18(1):127-150(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Proteomics, WHO, Neisseria gonorrhoeae, vaccine, antimicrobial resistance

Aleksandra Sikora
contact affiliation	Associate Professor | Department of Pharmaceutical Sciences | College of Pharmacy | Oregon State University
contact email	Aleksandra.Sikora@oregonstate.edu
lab head
Fadi El-Rami
contact affiliation	Oregon State University
contact email	elramif@oregonstate.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD008412
     1. Label: PRIDE project
     2. Name: Quantitative proteomics of the 2016 WHO Neisseria gonorrhoeae reference strains identifies vaccine candidates and antimicrobial resistance signatures.