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PXD008407

PXD008407 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLC-MSMS analysis of human urine to identify early diagnostic biomarkers for prostate cancer
DescriptionIn order to detect proteins sensitive and specific enough to detect early stages of PCa, we performed a complex comparative proteomic study analyzing urine as a source for non-invasive biomarkers. We compared urine samples from patients with early PCa stages and Gleason score between 6 and 7 with samples from patients with BPH and other urological cancers, namely bladder and renal. The main goal of this study was to discover a diagnostic biomarker or set of biomarkers in urine, sufficiently sensitive to detect PCa in its early stages and specific enough to separate the disease from BPH or other urological cancers.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:36:30.002.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD008407
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterKatarina Davalieva
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListOxidation; Carbamidomethyl
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-12-11 03:14:08ID requested
12018-01-02 03:32:57announced
22024-10-22 04:36:38announced2024-10-22: Updated project metadata.
Publication List
10.3390/proteomes6010001;
10.6019/PXD008407;
Davalieva K, Kiprijanovska S, Maleva Kostovska I, Stavridis S, Stankov O, Komina S, Petrusevska G, Polenakovic M, Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer. Proteomes, 6(1):(2017) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Human, LC-MSMS, Prostate cancer, Urine, diagnostic biomarkers
Contact List
Katarina Davalieva
contact affiliationResearch Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Department of Proteomics, Macedonian Academy of Sciences and Arts, Skopje, Krste Misirkov 2, 1000 Skopje, Republic of Macedonia
contact emailkatarina@manu.edu.mk
lab head
Katarina Davalieva
contact affiliationResearch Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, Skopje
contact emailkatarina@manu.edu.mk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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