PXD008353

PXD008353 is an original dataset announced via ProteomeXchange.

Title	Dynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons
Description	Excitotoxicity caused by over-stimulation of the ionotropic glutamate receptors is a key neuronal cell death process underpinning brain damage in acute and chronic neurological disorders such as ischaemic stroke, traumatic brain injury, and neurodegenerative diseases. Exactly how neurons die in excitotoxicity still remains unclear and is an important area of research in the field of neuroscience. In this current project we wanted to explore the global changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:42:22.851.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ashfaqul Hoque
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; monohydroxylated residue; dimethylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-04 00:44:52	ID requested
1	2019-03-07 00:59:59	announced
⏵ 2	2024-10-22 04:42:28	announced	2024-10-22: Updated project metadata.

Hoque A, Williamson NA, Ameen SS, Ciccotosto GD, Hossain MI, Oakhill JS, Ng DCH, Ang CS, Cheng HC, Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death. Cell Death Dis, 10(3):213(2019) [pubmed]

10.1038/s41419-019-1445-0;

curator keyword: Biological

submitter keyword: Neuron, phosphoproteome, proteome, excitotoxicity

Associate Professor Heung-Chin Cheng
contact affiliation	Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute Cell Signalling Research Laboratories The University of Melbourne Parkville, Victoria 3010, Australia
contact email	heung@unimelb.edu.au
lab head
Ashfaqul Hoque
contact affiliation	St Vincent's Institute of Medical Research (SVI)
contact email	ahoque@svi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD008353

PRIDE project URI

• PRIDE
  1. PXD008353
     1. Label: PRIDE project
     2. Name: Dynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons