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PXD008353

PXD008353 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons
DescriptionExcitotoxicity caused by over-stimulation of the ionotropic glutamate receptors is a key neuronal cell death process underpinning brain damage in acute and chronic neurological disorders such as ischaemic stroke, traumatic brain injury, and neurodegenerative diseases. Exactly how neurons die in excitotoxicity still remains unclear and is an important area of research in the field of neuroscience. In this current project we wanted to explore the global changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:42:22.851.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAshfaqul Hoque
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue; monohydroxylated residue; dimethylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-12-04 00:44:52ID requested
12019-03-07 00:59:59announced
22024-10-22 04:42:28announced2024-10-22: Updated project metadata.
Publication List
Hoque A, Williamson NA, Ameen SS, Ciccotosto GD, Hossain MI, Oakhill JS, Ng DCH, Ang CS, Cheng HC, Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death. Cell Death Dis, 10(3):213(2019) [pubmed]
10.1038/s41419-019-1445-0;
Keyword List
curator keyword: Biological
submitter keyword: Neuron, phosphoproteome, proteome, excitotoxicity
Contact List
Associate Professor Heung-Chin Cheng
contact affiliationDepartment of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute Cell Signalling Research Laboratories The University of Melbourne Parkville, Victoria 3010, Australia
contact emailheung@unimelb.edu.au
lab head
Ashfaqul Hoque
contact affiliationSt Vincent's Institute of Medical Research (SVI)
contact emailahoque@svi.edu.au
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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