PXD008353 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Dynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons |
Description | Excitotoxicity caused by over-stimulation of the ionotropic glutamate receptors is a key neuronal cell death process underpinning brain damage in acute and chronic neurological disorders such as ischaemic stroke, traumatic brain injury, and neurodegenerative diseases. Exactly how neurons die in excitotoxicity still remains unclear and is an important area of research in the field of neuroscience. In this current project we wanted to explore the global changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:42:22.851.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ashfaqul Hoque |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue; monohydroxylated residue; dimethylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-12-04 00:44:52 | ID requested | |
1 | 2019-03-07 00:59:59 | announced | |
⏵ 2 | 2024-10-22 04:42:28 | announced | 2024-10-22: Updated project metadata. |
Publication List
Hoque A, Williamson NA, Ameen SS, Ciccotosto GD, Hossain MI, Oakhill JS, Ng DCH, Ang CS, Cheng HC, Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death. Cell Death Dis, 10(3):213(2019) [pubmed] |
10.1038/s41419-019-1445-0; |
Keyword List
curator keyword: Biological |
submitter keyword: Neuron, phosphoproteome, proteome, excitotoxicity |
Contact List
Associate Professor Heung-Chin Cheng |
contact affiliation | Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute Cell Signalling Research Laboratories The University of Melbourne Parkville, Victoria 3010, Australia |
contact email | heung@unimelb.edu.au |
lab head | |
Ashfaqul Hoque |
contact affiliation | St Vincent's Institute of Medical Research (SVI) |
contact email | ahoque@svi.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD008353 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008353
- Label: PRIDE project
- Name: Dynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons