PXD008344

PXD008344 is an original dataset announced via ProteomeXchange.

Title	Human brain LC-MS/MS
Description	Citrullination as a post-translational modification has been described in a couple of autoimmune diseases like rheumatoid arthritis (RA) and multiples sclerosis (MS). We investigated citrullination brain tissue from MS patients and healthy individuals (HD). The myelin sheath proteins have been the focus of citrullination and neurodegenerative diseases like Alzheimers Disease (AD), Parkinsons and MS. We analysed whole brain tissue of MS patients and HD and established a catalogue of citrullinated proteins. Besides new citrullinated proteins we found additional citrullinated sites on the already described proteins: MBP, GFAP and Vimentin.
HostingRepository	PRIDE
AnnounceDate	2019-04-10
AnnouncementXML	Submission_2019-05-02_07:06:05.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wolfgang Faigle
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-01 00:29:39	ID requested
1	2019-04-10 06:08:53	announced
2	2019-05-02 06:29:55	announced	Updated publication reference for PubMed record(s): 31024521.
⏵ 3	2019-05-02 07:06:16	announced	Updated publication reference for PubMed record(s): 31024521.

Faigle W, Cruciani C, Wolski W, Roschitzki B, Puthenparampil M, Tomas-Ojer P, Sell, é, s-Moreno C, Zeis T, Jelcic I, Schaeren-Wiemers N, Sospedra M, Martin R, T Cells in Multiple Sclerosis. Front Immunol, 10():540(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Multiple Sclerosis (MS), pressure cycle technology (PCT), hydrophilic interaction liquid chromatography HILIC, mass spectrometry, citrullination, human post mortem brain tissue, post-translational modification, myelin basic protein, (MBP), neurodegeneration

Prof. Dr. Roland Martin
contact affiliation	Neuroimmunology and MS Research University Hospital Zurich Frauenklinikstrasse 26 8091 Zurich Switzerland
contact email	roland.martin@usz.ch
lab head
Wolfgang Faigle
contact affiliation	University Hospital Zurich
contact email	wolfgang.faigle@usz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/04/PXD008344

PRIDE project URI

• PRIDE
  1. PXD008344
     1. Label: PRIDE project
     2. Name: Human brain LC-MS/MS