PXD008302

PXD008302 is an original dataset announced via ProteomeXchange.

Title	Quantitative Proteomic Analysis of Pancreatic Cyst Fluid Proteins Associated with Malignancy in Intraductal Papillary Mucinous Neoplasms
Description	Intraductal papillary mucinous neoplasm (IPMN) is a benign tumor that grows within the pancreatic ducts characterized by the production of thick mucinous fluid by surrounding tumor cells. IPMN is the most important precursor lesion for pancreatic cancer that is the fourth most common cause of cancer deaths. Differentiating between low-grade dysplasia (LGD), high-grade dysplasia (HGD), and invasive intraductal papillary mucinous neoplasms (IPMNs) remains a diagnostic challenge with current biomarkers, necessitating the development of novel biomarkers that can distinguish IPMN malignancy. We investigated differentially expressed proteins among pancreatic cyst fluids consisted of LGD, HGD, and invasive IPMN patients by using our novel proteomic strategy, and finally we discovered pancreatic cyst fluid protein marker candidates that can predict the malignant potential of IPMNs.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:42:29.147.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Misol Do
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-11-27 03:39:23	ID requested
1	2018-05-01 02:40:32	announced
⏵ 2	2024-10-22 04:42:36	announced	2024-10-22: Updated project metadata.

Mann BF, Goetz JA, House MG, Schmidt CM, Novotny MV, Glycomic and proteomic profiling of pancreatic cyst fluids identifies hyperfucosylated lactosamines on the N-linked glycans of overexpressed glycoproteins. Mol Cell Proteomics, 11(7):M111.015792(2012) [pubmed]

10.1074/mcp.m111.015792;

curator keyword: Biomedical

submitter keyword: IPMN dysplasia, mucinous cystic neoplasm (MCN), biomarker candidates,pancreatic cyst fluid, intraductal papillary mucinous neoplasm (IPMN), LC-MS/MS

Youngsoo Kim
contact affiliation	Joint faculty of Department of Biomedical Sciences & Bioengineering, Seoul National University College of Medicine, 103 Daehak-ro, Seoul, Korea
contact email	biolab@snu.ac.kr
lab head
Misol Do
contact affiliation	Seoul National University College of Medicine
contact email	jm97129@naver.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD008302

PRIDE project URI

• PRIDE
  1. PXD008302
     1. Label: PRIDE project
     2. Name: Quantitative Proteomic Analysis of Pancreatic Cyst Fluid Proteins Associated with Malignancy in Intraductal Papillary Mucinous Neoplasms