PXD008278

PXD008278 is an original dataset announced via ProteomeXchange.

Title	Serum proteomics of Premature Carotid atherosclerosis: The Cardiovascular Risk in Young Finns Study
Description	Cardiovascular diseases represent a leading cause of deaths globally; of which atherosclerosis is a major contributor. Selective retention of circulating apolipoprotein B particles in the sub endothelial space by arterial wall proteoglycans and their subsequent modification is currently thought to be a hallmark of the disease. The exact mechanism responsible for lesion development is not fully understood. Currently, ultrasonic assessment of carotid artery intima media thickness (IMT) is commonly used as a pre-clinical marker of atherosclerosis. However, as the onset of atherosclerotic process and the appearance of carotid artery plaque can vary, the identification of additional biomarkers showing potential etiological aspects of disease is an important goal. This study describes the use of a label free mass spectrometry approach in the proteomics analysis of serum samples from control and atherosclerotic subjects. The samples were from a study cohort recruited in The Cardiovascular Risk in Young Finns Study, with a goal of identifying biomarkers for atherosclerosis. Samples from 43 individuals with a early non-obstructive plaques and 43 controls were used (Matched by age, sex, body size and systolic blood pressure).
HostingRepository	PRIDE
AnnounceDate	2018-07-30
AnnouncementXML	Submission_2018-07-30_02:58:26.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Santosh Bhosale
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	methylthiolated residue; monohydroxylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-11-23 03:09:18	ID requested
⏵ 1	2018-07-30 02:58:27	announced

Bhosale SD, Moulder R, Ven, ä, l, ä, inen MS, Koskinen JS, Pitk, ä, nen N, Juonala MT, K, ä, h, ö, nen MAP, Lehtim, ä, ki TJ, Viikari JSA, Elo LL, Goodlett DR, Lahesmaa R, Raitakari OT, Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis. Sci Rep, 8(1):9209(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Serum, Protoemics, Label free quantification, Atherosclerosis

Riitta Lahesmaa
contact affiliation	Turku Centre for Biotechnology
contact email	rilahes@utu.fi
lab head
Santosh Bhosale
contact affiliation	Turku Centre for Biotechnology, Turku, Finland
contact email	sadibh@utu.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD008278

PRIDE project URI

• PRIDE
  1. PXD008278
     1. Label: PRIDE project
     2. Name: Serum proteomics of Premature Carotid atherosclerosis: The Cardiovascular Risk in Young Finns Study