PXD008278 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Serum proteomics of Premature Carotid atherosclerosis: The Cardiovascular Risk in Young Finns Study |
| Description | Cardiovascular diseases represent a leading cause of
deaths globally; of which atherosclerosis is a major contributor.
Selective retention of circulating apolipoprotein B particles in the sub
endothelial space by arterial wall proteoglycans and their subsequent
modification is currently thought to be a hallmark of the disease. The
exact mechanism responsible for lesion development is not fully
understood. Currently, ultrasonic assessment of carotid artery intima
media thickness (IMT) is commonly used as a pre-clinical marker of
atherosclerosis. However, as the onset of atherosclerotic process and
the appearance of carotid artery plaque can vary, the identification of
additional biomarkers showing potential etiological aspects of disease
is an important goal. This study describes the use of a label free mass
spectrometry approach in the proteomics analysis of serum samples from
control and atherosclerotic subjects. The samples were from a study
cohort recruited in The Cardiovascular Risk in Young Finns Study, with a
goal of identifying biomarkers for atherosclerosis. Samples from 43
individuals with a early non-obstructive plaques and 43 controls were
used (Matched by age, sex, body size and systolic blood pressure). |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_04:42:23.282.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Santosh Bhosale |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | methylthiolated residue; monohydroxylated residue |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2017-11-23 03:09:18 | ID requested | |
| 1 | 2018-07-30 02:58:27 | announced | |
| ⏵ 2 | 2024-10-22 04:42:26 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.1038/s41598-018-27265-9; |
| Bhosale SD, Moulder R, Ven, ä, l, ä, inen MS, Koskinen JS, Pitk, ä, nen N, Juonala MT, K, ä, h, ö, nen MAP, Lehtim, ä, ki TJ, Viikari JSA, Elo LL, Goodlett DR, Lahesmaa R, Raitakari OT, Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis. Sci Rep, 8(1):9209(2018) [pubmed] |
Keyword List
| curator keyword: Biomedical |
| submitter keyword: Atherosclerosis,Serum, Label free quantification, Protoemics |
Contact List
| Riitta Lahesmaa |
|---|
| contact affiliation | Turku Centre for Biotechnology |
| contact email | rilahes@utu.fi |
| lab head | |
| Santosh Bhosale |
|---|
| contact affiliation | Turku Centre for Biotechnology, Turku, Finland |
| contact email | sadibh@utu.fi |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD008278 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008278
- Label: PRIDE project
- Name: Serum proteomics of Premature Carotid atherosclerosis: The Cardiovascular Risk in Young Finns Study
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