PXD008252

PXD008252 is an original dataset announced via ProteomeXchange.

Title	Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor
Description	The release of soluble ligands of activating Natural Killer (NK) cell receptors may represent a regulatory mechanism of NK cell function both in physiologic and in pathologic conditions. Here, we identified the extracellular matrix protein Nidogen-1 (NID1) as a ligand of NKp44, an important activating receptor expressed by activated NK cells. When released as soluble molecule, NID1 can regulate NK cell function by modulating NKp44-induced IFN-γ production or cytotoxicity. We also show that NID1 may be present at the cell surface. In this form or when bound to a solid support (bNID1), NID1 failed to induce NK cell cytotoxicity or cytokine release. However, analysis by mass spectrometry revealed that exposure to bNID1 can induce relevant changes in the proteomic profiles suggesting an effect on different, biological processes of human NK cells.
HostingRepository	PRIDE
AnnounceDate	2018-10-22
AnnouncementXML	Submission_2018-10-22_10:08:06.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chiara Lavarello
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2017-11-21 01:38:33	ID requested
⏵ 1	2018-10-22 10:08:11	announced

Gaggero S, Bruschi M, Petretto A, Parodi M, Del Zotto G, Lavarello C, Prato C, Santucci L, Barbuto A, Bottino C, Candiano G, Moretta A, Vitale M, Moretta L, Cantoni C, Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor. Oncoimmunology, 7(9):e1470730(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: NID1 NK NKp44 receptor

Andrea Petretto
contact affiliation	Ist G. Gaslini
contact email	andreapetretto@gaslini.org
lab head
Chiara Lavarello
contact affiliation	IGG
contact email	chiaralavarello@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD008252
     1. Label: PRIDE project
     2. Name: Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor