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PXD008246

PXD008246 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of novel LIMK2 phosphorylation substrates
DescriptionBreast cancer is the most common and a lethal form of cancer diagnosed in women worldwide. Although, effective treatment options for primary tumors are available, the majority of breast cancer-related deaths is caused by invasion of cells from primary tumor results in metastatic progression. Here we used a phopshoproteomic analysis to identify new targets of pro-invasive LIM kinase 2 (LIMK2) in invasive breast cancer cell lines. We show that Serine Arginine protein kinase 1 (SRPK1) is phosphorylated and activated by LIMK2 and LIMK2-SRPK1 signaling axis mediate the invasive behavior of breast cancer cells.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:11:33.143.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitternarendra wajapeyee
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-11-20 05:40:22ID requested
12020-08-30 22:58:20announced
22024-10-22 05:11:34announced2024-10-22: Updated project metadata.
Publication List
Malvi P, Janostiak R, Chava S, Manrai P, Yoon E, Singh K, Harigopal M, Gupta R, Wajapeyee N, LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1. Oncogenesis, 9(8):77(2020) [pubmed]
10.1038/s41389-020-00263-1;
Keyword List
curator keyword: Biomedical
submitter keyword: breast cancer,LIMK2, phosphorylation, invasion
Contact List
Narendra Wajapeyee
contact affiliationYale University
contact emailNarendra.Wajapeyee@yale.edu
lab head
narendra wajapeyee
contact affiliationUniversity of Alabama at Birmingham
contact emailnwajapey@uab.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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