PXD008245

PXD008245 is an original dataset announced via ProteomeXchange.

Title	A functional genomics screen identifies genes required for Schizosaccharomyces pombe meiosis
Description	Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects, however the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes and pathways important for meiosis, but the parts list is still poorly defined. Here we present a comprehensive catalogue of genes required for meiosis in the fission yeast, Schizosaccharomyces pombe. Our genome-wide functional screen surveyed all non-essential genes for roles in chromosome segregation and spore formation. Novel genes required at distinct stages of the meiotic chromosome segregation and differentiation programme were identified. Preliminary characterization implicated three of these genes in centrosome/spindle pole body function, centromere and cohesion function. Our findings represent a near-complete parts list of genes required for meiosis in fission yeast, providing a valuable resource to advance our molecular understanding of meiosis.
HostingRepository	PRIDE
AnnounceDate	2018-01-04
AnnouncementXML	Submission_2018-01-04_02:24:33.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Adele Marston
SpeciesList	scientific name: Schizosaccharomyces pombe; NCBI TaxID: 4896;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2017-11-20 05:40:02	ID requested
⏵ 1	2018-01-04 02:24:34	announced

Blyth J, Makrantoni V, Barton RE, Spanos C, Rappsilber J, Marston AL, Meiosis Identified Through a Functional Genomics Screen. Genetics, 208(2):589-603(2018) [pubmed]

curator keyword: Biological

submitter keyword: Meiosis, Schizosaccharomyces pombe, sporulation, chromosome segregation

Adele Marston
contact affiliation	WTCCB, University of Edinburgh
contact email	adele.marston@ed.ac.uk
lab head
Adele Marston
contact affiliation	University of Edinburgh
contact email	adele.marston@ed.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD008245
     1. Label: PRIDE project
     2. Name: A functional genomics screen identifies genes required for Schizosaccharomyces pombe meiosis