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DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2019-04-15
  • AnnouncementXML: Submission_2019-04-15_08:22:38.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Fernando J. Sialana
  • Title: Adherent and Spheroid Glioblastoma Proteomics
  • Description: Dendritic cell (DC)-based immunotherapy against glioblastoma multiforme is a novel treatment hope. Glioblastoma stem-like cells are, however, potentially causing immunoresistance. Glioblastoma cells cultured as gliomaspheres show a stem-like phenotype as opposed to classical adherent culture. They are thus a promising antigen source to specifically target glioblastoma stem-like cells via DC therapy and so overcome immunoresistance. Here we study the importance of gliomasphere-specific. Methodologically, we used 7 gliomaspheres, 3 of them patient-derived, as model system. Gliomasphere-specific protein expression was explored via quantitative proteomics.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
  • Instrument: Q Exactive Plus

Dataset History

VersionDatetimeStatusChangeLog Entry
02017-11-20 05:39:40ID requested
12019-04-15 08:22:39announced

Publication List

  1. Erhart F, Weiss T, Klingenbrunner S, Fischhuber K, Reitermaier R, Halfmann A, Blauensteiner B, Lötsch D, Spiegl-Kreinecker S, Berger W, Sialana FJ, Lubec G, Felzmann T, Dohnal A, Visus C, Spheroid glioblastoma culture conditions as antigen source for dendritic cell-based immunotherapy: spheroid proteins are survival-relevant targets but can impair immunogenic interferon γ production. Cytotherapy, 21(6):643-658(2019) [pubmed]

Keyword List

  1. curator keyword: Biomedical
  2. submitter keyword: Glioblastoma multiforme, dendritic cell, immunotherapy, gliomasphere, antigen source, quantitative proteomics

Contact List

    Gert Lubec
    • contact affiliation: University of Vienna
    • contact email: gert.lubec@lubeclab.com
    • lab head:
    Fernando J. Sialana
    • contact affiliation: Pharmaceutical Chemistry, University of Vienna
    • contact email: fsialana@yahoo.com
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List

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