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PXD008244

PXD008244 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAdherent and Spheroid Glioblastoma Proteomics
DescriptionDendritic cell (DC)-based immunotherapy against glioblastoma multiforme is a novel treatment hope. Glioblastoma stem-like cells are, however, potentially causing immunoresistance. Glioblastoma cells cultured as gliomaspheres show a stem-like phenotype as opposed to classical adherent culture. They are thus a promising antigen source to specifically target glioblastoma stem-like cells via DC therapy and so overcome immunoresistance. Here we study the importance of gliomasphere-specific. Methodologically, we used 7 gliomaspheres, 3 of them patient-derived, as model system. Gliomasphere-specific protein expression was explored via quantitative proteomics.
HostingRepositoryPRIDE
AnnounceDate2019-04-15
AnnouncementXMLSubmission_2019-04-15_08:22:38.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFernando J. Sialana
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-11-20 05:39:40ID requested
12019-04-15 08:22:39announced
Publication List
Erhart F, Weiss T, Klingenbrunner S, Fischhuber K, Reitermaier R, Halfmann A, Blauensteiner B, Lötsch D, Spiegl-Kreinecker S, Berger W, Sialana FJ, Lubec G, Felzmann T, Dohnal A, Visus C, Spheroid glioblastoma culture conditions as antigen source for dendritic cell-based immunotherapy: spheroid proteins are survival-relevant targets but can impair immunogenic interferon γ production. Cytotherapy, 21(6):643-658(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Glioblastoma multiforme, dendritic cell, immunotherapy, gliomasphere, antigen source, quantitative proteomics
Contact List
Gert Lubec
contact affiliationUniversity of Vienna
contact emailgert.lubec@lubeclab.com
lab head
Fernando J. Sialana
contact affiliationPharmaceutical Chemistry, University of Vienna
contact emailfsialana@yahoo.com
dataset submitter
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Dataset FTP location
PRIDE project URI
Repository Record List
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