PXD008244

PXD008244 is an original dataset announced via ProteomeXchange.

Title	Adherent and Spheroid Glioblastoma Proteomics
Description	Dendritic cell (DC)-based immunotherapy against glioblastoma multiforme is a novel treatment hope. Glioblastoma stem-like cells are, however, potentially causing immunoresistance. Glioblastoma cells cultured as gliomaspheres show a stem-like phenotype as opposed to classical adherent culture. They are thus a promising antigen source to specifically target glioblastoma stem-like cells via DC therapy and so overcome immunoresistance. Here we study the importance of gliomasphere-specific. Methodologically, we used 7 gliomaspheres, 3 of them patient-derived, as model system. Gliomasphere-specific protein expression was explored via quantitative proteomics.
HostingRepository	PRIDE
AnnounceDate	2019-04-15
AnnouncementXML	Submission_2019-04-15_08:22:38.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fernando J. Sialana
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2017-11-20 05:39:40	ID requested
⏵ 1	2019-04-15 08:22:39	announced

Erhart F, Weiss T, Klingenbrunner S, Fischhuber K, Reitermaier R, Halfmann A, Blauensteiner B, L, ö, tsch D, Spiegl-Kreinecker S, Berger W, Sialana FJ, Lubec G, Felzmann T, Dohnal A, Visus C, production. Cytotherapy, 21(6):643-658(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Glioblastoma multiforme, dendritic cell, immunotherapy, gliomasphere, antigen source, quantitative proteomics

Gert Lubec
contact affiliation	University of Vienna
contact email	gert.lubec@lubeclab.com
lab head
Fernando J. Sialana
contact affiliation	Pharmaceutical Chemistry, University of Vienna
contact email	fsialana@yahoo.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/04/PXD008244

PRIDE project URI

• PRIDE
  1. PXD008244
     1. Label: PRIDE project
     2. Name: Adherent and Spheroid Glioblastoma Proteomics