PXD008222

PXD008222 is an original dataset announced via ProteomeXchange.

Title	The Proteomic Landscape of Triple-Negative Breast Cancer
Description	Triple-negative breast cancer is a heterogeneous disease characterized by poor clinical outcomes and a shortage of targeted treatment options. To discover molecular features of triple-negative breast cancer, we performed quantitative proteomics analysis of twenty human-derived breast cell lines and four primary breast tumors to a depth of more than 12,000 distinct proteins. We used this data to identify breast cancer subtypes at the protein level and demonstrate the precise quantification of biomarkers, signaling proteins, and biological pathways by mass spectrometry. We integrated proteomics data with exome sequence resources to identify genomic aberrations that affect protein expression. We performed a high-throughput drug screen to identify protein markers of drug sensitivity and understand the mechanisms of drug resistance. The genome and proteome provide complementary information that, when combined, yield a powerful engine for therapeutic discovery. This resource is available to the cancer research community to catalyze further analysis and investigation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:41:38.829.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martin Frejno
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-11-16 00:17:51	ID requested
1	2017-12-12 08:00:44	announced
⏵ 2	2024-10-22 04:41:46	announced	2024-10-22: Updated project metadata.

10.1016/j.celrep.2015.04.059;

Lawrence RT, Perez EM, Hern, á, ndez D, Miller CP, Haas KM, Irie HY, Lee SI, Blau CA, Vill, é, n J, The Proteomic Landscape of Triple-Negative Breast Cancer. Cell Rep, 11(6):990(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: Human

Judit Villén
contact affiliation	University of Washington
contact email	jvillen@uw.edu
lab head
Martin Frejno
contact affiliation	TUM
contact email	martin.frejno@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/12/PXD008222

PRIDE project URI

• PRIDE
  1. PXD008222
     1. Label: PRIDE project
     2. Name: The Proteomic Landscape of Triple-Negative Breast Cancer