PXD008130

PXD008130 is an original dataset announced via ProteomeXchange.

Title	Human platelet β-catenin interaction proteome
Description	In nucleated cells, β-catenin, the key downstream effector of this pathway, is a dual function protein, regulating the coordination of gene transcription and cell–cell adhesion. The specific role of β-catenin in the anucleate platelet however remains elusive. Here, we performed a label-free quantitative proteomic analysis of β-catenin immunoprecipitates from human platelets identifying 9 co-immunoprecipitating proteins. GO biological pathway analysis revealed a significant enrichment of specific functional terms including 'cell adhesion', 'cell junction organization' and ‘adherens junction organization'. Our bioinformatics data suggests that human platelet β-catenin may be involved in facilitating cell adhesion and cell junctions. We found three proteins co-immunoprecipitating with β-catenin under both resting and activated conditions, four proteins under resting condition only and two proteins under activated condition only.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:41:58.262.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Paulina Szklanna
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-11-03 08:29:21	ID requested
1	2018-07-05 05:10:04	announced
⏵ 2	2024-10-22 04:42:06	announced	2024-10-22: Updated project metadata.

10.1002/pmic.201700419;

Maguire PB, Donlon T, Parsons M, Wynne K, Dillon E, N, í, , Á, inle F, Szklanna PB, -Catenin With Cadherin Adherens Junctions in Resting Human Platelets. Proteomics, 18(9):e1700419(2018) [pubmed]

submitter keyword: Human, mass spectrometry, label-free quantitation, Platelets, β-catenin, Co-immunoprecipitation

Patricia B. Maguire
contact affiliation	SPHERE research group, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin
contact email	patricia.maguire@ucd.ie
lab head
Paulina Szklanna
contact affiliation	University College Dublin
contact email	paulina.szklanna@ucdconnect.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD008130

PRIDE project URI

• PRIDE
  1. PXD008130
     1. Label: PRIDE project
     2. Name: Human platelet β-catenin interaction proteome