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PXD008130

PXD008130 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman platelet β-catenin interaction proteome
DescriptionIn nucleated cells, β-catenin, the key downstream effector of this pathway, is a dual function protein, regulating the coordination of gene transcription and cell–cell adhesion. The specific role of β-catenin in the anucleate platelet however remains elusive. Here, we performed a label-free quantitative proteomic analysis of β-catenin immunoprecipitates from human platelets identifying 9 co-immunoprecipitating proteins. GO biological pathway analysis revealed a significant enrichment of specific functional terms including 'cell adhesion', 'cell junction organization' and ‘adherens junction organization'. Our bioinformatics data suggests that human platelet β-catenin may be involved in facilitating cell adhesion and cell junctions. We found three proteins co-immunoprecipitating with β-catenin under both resting and activated conditions, four proteins under resting condition only and two proteins under activated condition only.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:41:58.262.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPaulina Szklanna
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-11-03 08:29:21ID requested
12018-07-05 05:10:04announced
22024-10-22 04:42:06announced2024-10-22: Updated project metadata.
Publication List
10.1002/pmic.201700419;
Maguire PB, Donlon T, Parsons M, Wynne K, Dillon E, N, í, , Á, inle F, Szklanna PB, -Catenin With Cadherin Adherens Junctions in Resting Human Platelets. Proteomics, 18(9):e1700419(2018) [pubmed]
Keyword List
submitter keyword: Human, mass spectrometry, label-free quantitation, Platelets, β-catenin, Co-immunoprecipitation
Contact List
Patricia B. Maguire
contact affiliationSPHERE research group, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin
contact emailpatricia.maguire@ucd.ie
lab head
Paulina Szklanna
contact affiliationUniversity College Dublin
contact emailpaulina.szklanna@ucdconnect.ie
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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