PXD008130 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human platelet β-catenin interaction proteome |
Description | In nucleated cells, β-catenin, the key downstream effector of this pathway, is a dual function protein, regulating the coordination of gene transcription and cell–cell adhesion. The specific role of β-catenin in the anucleate platelet however remains elusive. Here, we performed a label-free quantitative proteomic analysis of β-catenin immunoprecipitates from human platelets identifying 9 co-immunoprecipitating proteins. GO biological pathway analysis revealed a significant enrichment of specific functional terms including 'cell adhesion', 'cell junction organization' and ‘adherens junction organization'. Our bioinformatics data suggests that human platelet β-catenin may be involved in facilitating cell adhesion and cell junctions. We found three proteins co-immunoprecipitating with β-catenin under both resting and activated conditions, four proteins under resting condition only and two proteins under activated condition only. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:41:58.262.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Paulina Szklanna |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-11-03 08:29:21 | ID requested | |
1 | 2018-07-05 05:10:04 | announced | |
⏵ 2 | 2024-10-22 04:42:06 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1002/pmic.201700419; |
Maguire PB, Donlon T, Parsons M, Wynne K, Dillon E, N, í, , Á, inle F, Szklanna PB, -Catenin With Cadherin Adherens Junctions in Resting Human Platelets. Proteomics, 18(9):e1700419(2018) [pubmed] |
Keyword List
submitter keyword: Human, mass spectrometry, label-free quantitation, Platelets, β-catenin, Co-immunoprecipitation |
Contact List
Patricia B. Maguire |
contact affiliation | SPHERE research group, School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin |
contact email | patricia.maguire@ucd.ie |
lab head | |
Paulina Szklanna |
contact affiliation | University College Dublin |
contact email | paulina.szklanna@ucdconnect.ie |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD008130 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008130
- Label: PRIDE project
- Name: Human platelet β-catenin interaction proteome