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PXD008071

PXD008071 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSystems Signature Reveals Unique Remission-path of Diabetes Generated by Gastric Bypass Surgery
DescriptionGastric bypass surgery (GBP) emerging as a powerful tool for treatment of obesity has been applied for remission of diabetes. However, the GBP global molecular effects on diabetes remission independent of weight loss remain largely unknown. We profiled plasma metabolites and proteins of 10 normoglycemic obese (NO) and 9 diabetic obese (DO) patients at 1-week, 3-months and 1-year stages after Roux-en-Y gastric bypass (RYGB) as well pre-RYGB stage, by which 146 proteins and 128 metabolites were detected from both NO and DO groups at all four stages. By analyzing a set of bi-molecular associations among the corresponding network of the subjects with our newly developed computational method, we defined the representing physiological states (called the edge-states, in contrast to the traditional node-states) and the related molecular networks of NO and DO patients, respectively. The PCA results and hubnetworks of NO subjects were significantly different from those of DO patients; particularly, the hub-network rearrangement of both groups differentially went through after RYGB. In conclusion, by developing network-based systems signatures rather than relying on individual molecules, we for the first time reveal that RYGB generates a unique recovering-path for diabetes remission independent of weight loss.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:41:13.514.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterdandan wang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Velos; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-10-30 02:40:56ID requested
12017-12-13 05:56:46announced
22018-02-15 02:21:42announcedUpdated publication reference for PubMed record(s): 29422288.
32024-10-22 04:41:19announced2024-10-22: Updated project metadata.
Publication List
10.1016/j.ebiom.2018.01.018;
Li QR, Wang ZM, Wewer Albrechtsen NJ, Wang DD, Su ZD, Gao XF, Wu QQ, Zhang HP, Zhu L, Li RX, Jacobsen S, J, ø, rgensen NB, Dirksen C, Bojsen-M, ø, ller KN, Petersen JS, Madsbad S, Clausen TR, Diderichsen B, Chen LN, Holst JJ, Zeng R, Wu JR, Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery. EBioMedicine, 28():234-240(2018) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Network,Gastric bypass,Diabetes,Systems signature
Contact List
Rong Zeng
contact affiliationKey Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Department of Life Sciences, ShanghaiTech University
contact emailzr@sibcb.ac.cn
lab head
dandan wang
contact affiliationstudent
contact emailwangdandan2015@sibcb.ac.cn
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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