PXD008071

PXD008071 is an original dataset announced via ProteomeXchange.

Title	Systems Signature Reveals Unique Remission-path of Diabetes Generated by Gastric Bypass Surgery
Description	Gastric bypass surgery (GBP) emerging as a powerful tool for treatment of obesity has been applied for remission of diabetes. However, the GBP global molecular effects on diabetes remission independent of weight loss remain largely unknown. We profiled plasma metabolites and proteins of 10 normoglycemic obese (NO) and 9 diabetic obese (DO) patients at 1-week, 3-months and 1-year stages after Roux-en-Y gastric bypass (RYGB) as well pre-RYGB stage, by which 146 proteins and 128 metabolites were detected from both NO and DO groups at all four stages. By analyzing a set of bi-molecular associations among the corresponding network of the subjects with our newly developed computational method, we defined the representing physiological states (called the edge-states, in contrast to the traditional node-states) and the related molecular networks of NO and DO patients, respectively. The PCA results and hubnetworks of NO subjects were significantly different from those of DO patients; particularly, the hub-network rearrangement of both groups differentially went through after RYGB. In conclusion, by developing network-based systems signatures rather than relying on individual molecules, we for the first time reveal that RYGB generates a unique recovering-path for diabetes remission independent of weight loss.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:41:13.514.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	dandan wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-10-30 02:40:56	ID requested
1	2017-12-13 05:56:46	announced
2	2018-02-15 02:21:42	announced	Updated publication reference for PubMed record(s): 29422288.
⏵ 3	2024-10-22 04:41:19	announced	2024-10-22: Updated project metadata.

10.1016/j.ebiom.2018.01.018;

Li QR, Wang ZM, Wewer Albrechtsen NJ, Wang DD, Su ZD, Gao XF, Wu QQ, Zhang HP, Zhu L, Li RX, Jacobsen S, J, ø, rgensen NB, Dirksen C, Bojsen-M, ø, ller KN, Petersen JS, Madsbad S, Clausen TR, Diderichsen B, Chen LN, Holst JJ, Zeng R, Wu JR, Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery. EBioMedicine, 28():234-240(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Network,Gastric bypass,Diabetes,Systems signature

Rong Zeng
contact affiliation	Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Department of Life Sciences, ShanghaiTech University
contact email	zr@sibcb.ac.cn
lab head
dandan wang
contact affiliation	student
contact email	wangdandan2015@sibcb.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/12/PXD008071

PRIDE project URI

• PRIDE
  1. PXD008071
     1. Label: PRIDE project
     2. Name: Systems Signature Reveals Unique Remission-path of Diabetes Generated by Gastric Bypass Surgery